MULTIPLICATION OF RUBELLA AND MEASLES VIRUSES IN PRIMARY RAT NEURAL CELL-CULTURES - RELEVANCE TO A POSTULATED TRIGGERING MECHANISM FOR MULTIPLE-SCLEROSIS
MULTIPLICATION OF RUBELLA AND MEASLES VIRUSES IN PRIMARY RAT NEURAL CELL-CULTURES - RELEVANCE TO A POSTULATED TRIGGERING MECHANISM FOR MULTIPLE-SCLEROSIS
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DOI：
10.1111/j.1365-2990.1991.tb00727.x
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发表时间：
1991-08-01
影响因子：
5
通讯作者：
SHEAHAN, BJ
中科院分区：
文献类型：
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作者：
ATKINS, GJ;MOONEY, DA;SHEAHAN, BJ
风疹病毒增殖到低滴度，并在大鼠神经胶质细胞培养物中产生部分细胞病变效应。 抗半乳糖苷染色显示，这种细胞病变效应涉及少突胶质细胞的解体。 风疹病毒感染髓鞘神经细胞培养物后产生类似的效果，但在纯神经元培养物中不能检测到病毒增殖。 发现麻疹病毒在神经元和神经胶质细胞的原代培养物中繁殖并产生细胞病变效应。 这些结果进行了讨论，麻疹和风疹病毒触发人类多发性硬化症的能力。
Rubella virus multiplied to low titre and produced a partial cytopathic effect in rat glial cell cultures. Anti-galactocerebroside staining showed that this cytopathic effect involved the disintegration of oligodendrocytes. A similar effect was produced following infection of myelinating neural cell cultures with rubella virus, but virus multiplication could not be detected in pure neuron cultures. Measles virus was found to multiply and produce a cytopathic effect in primary cultures of both neurons and glial cells. These results are discussed in relation to the ability of measles and rubella viruses to trigger human multiple sclerosis.