Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study
Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study
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DOI：
10.1177/0271678x16669366
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发表时间：
2017-07-01
影响因子：
6.3
通讯作者：
Cunnane, Stephen C.
中科院分区：
文献类型：
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作者：
Courchesne-Loyer, Alexandre;Croteau, Etienne;Cunnane, Stephen C.
酮（主要是羟基丁酸酯和乙酰乙酸酯（AcAc））是人类大脑葡萄糖的重要替代燃料，但大脑对它们的利用仍然知之甚少。我们的目的是使用正电子发射断层扫描（PET）评估饮食诱导的中度酮症对健康成人脑乙酰乙酸（CMRa）和葡萄糖（CMRglc）代谢率的影响。10名参与者（35 +/- 15岁）接受了4天的极高脂肪生酮饮食（KD）（4.5：1;脂质：蛋白质加碳水化合物）。在KD之前和之后分别用示踪剂C-11-AcAc和F-18-氟脱氧葡萄糖（F-18-FDG）通过PET定量CMRa和CMRglc。KD期间，血浆酮升高8倍（p=0.005），而血糖降低24%（p=0.005）。CMRa增加了6倍（p=0.005），而CMRglc在KD上下降了20%（p=0.014）。血浆酮与CMRa呈正相关（r=0.93; p
Ketones (principally -hydroxybutyrate and acetoacetate (AcAc)) are an important alternative fuel to glucose for the human brain, but their utilisation by the brain remains poorly understood. Our objective was to use positron emission tomography (PET) to assess the impact of diet-induced moderate ketosis on cerebral metabolic rate of acetoacetate (CMRa) and glucose (CMRglc) in healthy adults. Ten participants (35 +/- 15 y) received a very high fat ketogenic diet (KD) (4.5:1; lipid:protein plus carbohydrates) for four days. CMRa and CMRglc were quantified by PET before and after the KD with the tracers, C-11-AcAc and F-18-fluorodeoxyglucose (F-18-FDG), respectively. During the KD, plasma ketones increased 8-fold (p=0.005) while plasma glucose decreased by 24% (p=0.005). CMRa increased 6-fold (p=0.005), whereas CMRglc decreased by 20% (p=0.014) on the KD. Plasma ketones were positively correlated with CMRa (r=0.93; p