ADDITION OF COLCHICINE-TUBULIN COMPLEX TO MICROTUBULE ENDS - MECHANISM OF SUBSTOICHIOMETRIC COLCHICINE POISONING
ADDITION OF COLCHICINE-TUBULIN COMPLEX TO MICROTUBULE ENDS - MECHANISM OF SUBSTOICHIOMETRIC COLCHICINE POISONING
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DOI：
10.1073/pnas.74.8.3466
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发表时间：
1977-01-01
影响因子：
11.1
通讯作者：
WILSON, L
中科院分区：
文献类型：
--
作者：
MARGOLIS, RL;WILSON, L
秋水仙碱通过一种不寻常的亚化学计量中毒机制阻断[牛肉]微管聚合，通过多种实验方法进行了研究。秋水仙碱可能通过添加到微管末端作为秋水仙碱-微管蛋白复合物发挥作用。
Colchicine which blocks [beef] microtubule polymerization by an unusual substoichiometric poisoning mechanism, was investigated with several experimental approaches. Colchicine probably acts by addition to microtubule ends as a colchicine-tubulin complex.