Synthesis, Biological Evaluation, and Molecular Docking of Ugi Products Containing a Zinc-Chelating Moiety as Novel Inhibitors of Histone Deacetylases
Synthesis, Biological Evaluation, and Molecular Docking of Ugi Products Containing a Zinc-Chelating Moiety as Novel Inhibitors of Histone Deacetylases
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DOI：
10.1021/jm801529c
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发表时间：
2009-05-14
影响因子：
7.3
通讯作者：
Pirali, Tracey
中科院分区：
文献类型：
--
作者：
Grolla, Ambra A.;Podesta, Valeria;Pirali, Tracey
HDAC抑制剂在治疗癌症方面显示出巨大的前景。作为探索HDAC抑制剂SAR的更广泛努力的一部分，介绍了含有锌螯合部分的新型UGI产品的合成、生物学评价和分子对接。一种化合物显示出比SARA更好的抑制能力，表明受阻的亲脂残基嫁接在α-氨基酰胺的多肽支架上可以有利于与酶的相互作用。
HDAC inhibitors show great promise for the treatment of cancer. AS part of a broader effort to explore the SAR of HDAC inhibitors, synthesis, biological evaluation, and molecular docking of novel Ugi products containing a zinc-chelating moiety are presented. One compound shows improved inhibitory potencies compared to SARA, demonstrating that hindered lipophilic residues grafted on the peptide scaffold of the alpha-aminoacylamides can be favorable in the interaction with the enzyme.