Growth hormone and insulin-like growth factor-I as anabolic agents.
Growth hormone and insulin-like growth factor-I as anabolic agents.
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DOI：
10.1097/00075197-199805000-00004
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发表时间：
1998-05-01
影响因子：
3.1
通讯作者：
Welle, S
中科院分区：
文献类型：
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作者：
Welle, S
生长激素缺乏和正常衰老时生长激素和胰岛素样生长因子-I浓度降低与肌肉质量和力量减少以及肌肉蛋白质合成减慢有关。最近的研究已经解决了生长激素和胰岛素样生长因子-I在成人（包括老年人）中具有合成代谢作用的假设。这些激素刺激全身和肌肉蛋白质合成，至少在某些条件下。有越来越多的证据证明长期服用生长激素可以促进生长激素缺乏的成年人的肌肉生长。然而，对老年人肌肉质量和功能的长期影响似乎不足以证明广泛的激素替代疗法是有益的。这些激素可能是有用的合成代谢剂，以抵消肌肉萎缩在其他条件下，包括手术应激，肾功能衰竭，肌营养不良症，糖皮质激素管理和艾滋病毒感染，但需要更多的临床试验，以确定蛋白质合成代谢作用的功能意义在这些条件下。
The reduced growth hormone and insulin-like growth factor-I concentrations in growth hormone deficiency and normal ageing are associated with reduced muscle mass and strength, and slower muscle protein synthesis. Recent research has addressed the hypothesis that growth hormone and insulin-like growth factor-I have an anabolic effect in adults, including the elderly. These hormones stimulate whole-body and muscle protein synthesis, at least under some conditions. There is increasing evidence to justify long-term administration of growth hormone to promote muscle growth in growth hormone deficient adults. However, the long-term effects on muscle mass and function in the elderly do not seem beneficial enough to justify widespread hormone replacement therapy. These hormones may be useful anabolic agents to counteract muscle wasting under other conditions, including surgical stress, renal failure, muscular dystrophy, glucocorticoid administration and HIV infection, but more clinical trials are needed to determine the functional significance of the protein anabolic effects under these conditions.