CAROTID-BODY GRAFTS INDUCE CHEMOSENSITIVITY IN MUSCLE NERVE-FIBERS OF THE CAT
CAROTID-BODY GRAFTS INDUCE CHEMOSENSITIVITY IN MUSCLE NERVE-FIBERS OF THE CAT
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DOI：
10.1016/0006-8993(83)90793-x
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发表时间：
1983-01-01
期刊：
影响因子：
2.9
通讯作者：
EYZAGUIRRE, C
中科院分区：
文献类型：
--
作者：
MONTIBLOCH, L;STENSAAS, LJ;EYZAGUIRRE, C
在8只猫上，通过将颈动脉体移植到肌腱上，并用肌神经重新支配该器官，测试了颈动脉体实质细胞改变神经纤维生理特性的能力。移植后94~174天，对支配肌腱的神经进行电生理记录。在有自发活动的再生神经纤维中，40%对肌肉拉伸、缺氧、NaCN、乙酰胆碱、尼古丁和多巴胺有反应，这显然是由于球体细胞和肌梭的双重神经支配所致。EM检查的6例移植物中，5例含有由轴突终末支配的活体球体细胞。无论是正常的肌腱神经还是再生为脂肪组织的神经或移植到一个无效的颈动脉小体上的神经都没有化学感受性，尽管这些移植物含有大量的有髓小轴突，表明有广泛的神经再生。颈动脉小体细胞能够在轴突中诱导化学感觉特性，而这些特性通常辅助机械感觉功能。
The ability of carotid body parenchymal cells to change the physiological properties of nerve fibers was tested in 8 cats by transplanting the carotid body to the tenuissimus muscle and reinnervating the organ with the muscle nerve. After the transplant, 94-174 days, electrophysiological recordings were obtained from the reinnervating tenuissimus nerves. Of the regenerating nerve fibers having spontaneous activity 40% responded to muscle stretch, hypoxia, NaCN, ACh [acetylcholine], nicotine and dopamine, apparently because of dual innervation of glomus cells and muscle spindles. Of 6 transplants examined by EM, 5 contained viable glomus cells innervated by axon terminals. Neither the normal tenuissimus nerve nor the same nerve regenerating into adipose tissue grafts or to one non-viable carotid body transplant showed chemosensory properties although these grafts contained numerous, small myelinated axons indicative of extensive nerve regeneration. Carotid body cells are capable of inducing chemosensory properties in axons that normally subserve a mechanosensory function.