Squamous cell carcinoma arising from thyroglossal duct remnants: Report of a case and results of immunohistochemical studies
Squamous cell carcinoma arising from thyroglossal duct remnants: Report of a case and results of immunohistochemical studies
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甲状舌管残余鳞状细胞癌一例报告及免疫组化研究结果
DOI：
10.1007/bf02385793
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发表时间：
1997
期刊：
影响因子：
2.5
通讯作者：
J. Amano
中科院分区：
文献类型：
--
作者：
Y. Hama;A. Sugenoya;Shinya Kobayashi;N. Itoh;J. Amano
我们报告的情况下，一个57岁的男性发现有鳞状细胞癌（SCC）引起甲状腺舌管残余。病人在他的前颈部有一个无症状的肿瘤，触诊时无法移动。穿刺活检细胞学显示为V级恶性肿瘤，有许多不典型簇和明显的角化。术前放疗后，采用Sistrunk手术进行根治性手术并进行双侧颈部清扫。组织病理学检查证实了中度分化SCC的诊断，但在囊肿壁上发现纤毛柱状上皮，没有正常的鳞状细胞层。此外，免疫组织化学研究显示肿瘤甲状腺球蛋白染色阴性，但细胞角蛋白和癌胚抗原阳性。这些组织病理学结果证明是由于甲状舌管纤毛柱状上皮发生鳞状化生。因此，鳞状细胞癌可能起源于甲状舌管残余的化生部分。虽然甲状腺舌管SCC的预后不如乳头状癌的预后乐观，但该患者术后7年未见复发迹象。这表明我们治疗这种罕见疾病的方法是有效的。
We report on the case of a 57-year-old male found to have squamous cell carcinoma (SCC) arising from thyroglossal duct remnants. The patient presented with an asymptomatic tumor in his anterior neck which was immovable on palpation. Aspiration biopsy cytology revealed class V malignancy with many atypical clusters and marked keratinization. After preoperative radiation, a radical operation employing Sistrunk's procedure with bilateral neck dissection was performed. Histopathological examination confirmed a diagnosis of moderately differentiated SCC, but revealed ciliated columnar epithelium in the walls of the cyst without a normal layer of squamous cells. Furthermore, immunohistochemical studies demonstrated the tumor to be negative for thyroglobulin staining, but positive for cytokeratin and carcinoembryonic antigen. These histopathological findings proved attributable to squamous metaplasia occurring in the ciliated columnar epithelium of the thyroglossal duct. Thus, SCC might originate in the metaplastic portion of the thyroglossal duct remnants. Although the prognosis associated with SCC in the thyroglossal duct is not as optimistic as that associated with papillary carcinoma, no evidence of recurrence has been observed in this patient in the 7 years since his operation. This suggests the effectiveness of our therapeutic approach for this unusual disease.