Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines
Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines
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DOI：
10.1021/bp025597w
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发表时间：
2002-09-01
影响因子：
2.9
通讯作者：
Klibanov, AM
中科院分区：
文献类型：
--
作者：
Lin, J;Qiu, SY;Klibanov, AM
我们之前发现，用某些长聚（乙烯基- n -烷基吡啶）链共价涂覆玻璃和塑料载玻片，使所得到的表面能够杀死接触到的各种空气传播和水传播的细菌。在目前的研究中，这些发现已经扩展到一个不相关的聚合物类，聚乙烯亚胺（PEIs）。烷基化PEIs附着在平坦的宏观表面和纳米颗粒表面上，使这些材料对革兰氏阳性和革兰氏阴性致病菌都具有很强的杀菌作用。本文对固定化PEI进行了系统的化学修饰，揭示了聚合物结构与所得涂层的抗菌效率之间的关系。
We previously discovered that covalently coating glass and plastic slides with certain long poly(vinyl-N-alkylpyridinium) chains enables the resultant surfaces to kill a variety of airborne and waterborne bacteria on contact. In the present study, these findings have been extended to an unrelated polymer class, polyethylenimines (PEIs). Alkylated PEIs attached to flat macroscopic surfaces and to those of nanoparticles make these materials highly bactericidal toward both Gram-positive and Gram-negative pathogenic bacteria. Systematic chemical modifications of the immobilized PEI conducted herein shed light on the relationship between the structure of the polymer and the antibacterial efficiency of the resultant coating.