Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice
Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice
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DOI：
10.1093/intimm/12.6.915
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发表时间：
2000-06-01
影响因子：
4.4
通讯作者：
Erikson, J
中科院分区：
文献类型：
--
作者：
Eaton-Bassiri, AS;Mandik-Nayak, L;Erikson, J
Aging is characterized by a decline In humoral immunity and a concommitant increased incidence of anti-DNA and other autoantibodies. To define how the regulation of autoreactive B cells is altered with age, we have used BALB/c mice with an Ig heavy H chain transgene to track the fate of anti-double-stranded (ds) DNA a cells in vivo. In young adult mice, anti-dsDNA a cells are developmentally arrested and excluded from the splenic a cell follicle, whereas in most aged mice they are mature and localize within the B cell follicle, Furthermore, we have detailed global changes in lymphoid architecture that accompany aging: CD4(+) T cells are found not only in the periarteriolar lymphoid sheath, but also in the a cell follicles. Strikingly, these disruptions are similar to those that precede serum anti-dsDNA antibody expression in autoimmune MRL-lpr/lpr mice.
