Effect of reducing the nicotine content of cigarettes on cigarette smoking behavior and tobacco smoke toxicant exposure: 2-year follow up
Effect of reducing the nicotine content of cigarettes on cigarette smoking behavior and tobacco smoke toxicant exposure: 2-year follow up
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DOI：
10.1111/add.12978
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发表时间：
2015-10-01
期刊：
影响因子：
6
通讯作者：
Jacob, Peyton, III
中科院分区：
文献类型：
--
作者：
Benowitz, Neal L.;Nardone, Natalie;Jacob, Peyton, III
背景和目的在美国已经提出了广泛强制性的降低香烟的尼古丁含量（RNC），以减少香烟的成瘾性，防止新吸烟者成瘾并促进已建立的吸烟者戒烟。本研究的主要目的是确定是否7个月后吸烟非常低尼古丁含量的香烟（VLNC），然后返回到自己的香烟，吸烟者将表现出持续降低尼古丁摄入量与基线或戒烟。MethodsIn一个社区为基础的诊所135吸烟者不感兴趣的戒烟被随机分为两组之一。一个研究组抽他们常用品牌的香烟，然后是五种尼古丁含量逐渐降低的研究香烟，每种香烟持续1个月，然后是6个月的最低尼古丁水平（0.5毫克/支）（53名受试者），然后是12个月的无干预（30名受试者完成）。对照组在相同的时间内吸烟（50名受试者在6个月时，38名完成）。结果在VLNC吸烟7个月后，尼古丁摄入量仍低于基线水平（血浆可替宁149对250 ng/ml，P
Background and AimsA broadly mandated reduction of the nicotine content (RNC) of cigarettes has been proposed in the United States to reduce the addictiveness of cigarettes, to prevent new smokers from becoming addicted and to facilitate quitting in established smokers. The primary aim of this study was to determine whether following 7months of smoking very low nicotine content cigarettes (VLNC), and then returning to their own cigarettes, smokers would demonstrate persistently reduced nicotine intake compared with baseline or quit smoking.MethodsIn a community-based clinic 135 smokers not interested in quitting were randomized to one of two groups. A research group smoked their usual brand of cigarettes, followed by five types of research cigarettes with progressively lower nicotine content, each for 1month, followed by 6months at the lowest nicotine level (0.5mg/cigarette) (53subjects) and then 12months with no intervention (30subjects completed). A control group smoked their usual brand for the same period of time (50subjects at 6months, 38completed). Smoking behavior, biomarkers of nicotine intake and smoke toxicant exposure were measured.ResultsAfter 7months smoking VLNC, nicotine intake remained below baseline (plasma cotinine 149 versus 250ng/ml, P