Relation of retinal blood flow and retinal oxygen extraction during stimulation with diffuse luminance flicker.
Relation of retinal blood flow and retinal oxygen extraction during stimulation with diffuse luminance flicker.
复制标题
散布亮度闪烁刺激期间，视网膜血流和视网膜征氧的关系的关系。
DOI：
10.1038/srep18291
复制
发表时间：
2015-12-17
影响因子：
4.6
通讯作者：
Schmetterer L
中科院分区：
文献类型：
--
作者：
Palkovits S;Lasta M;Told R;Schmidl D;Werkmeister R;Cherecheanu AP;Garhöfer G;Schmetterer L
大脑和视网膜的血流依赖于局部神经元的活动。几项研究量化了活动期间脑血流量和耗氧量的增加。在本研究中，我们调查了视网膜血流和氧提取的变化之间的关系，在刺激与弥漫性亮度闪烁和呼吸气体混合物的影响与不同分数的O2（FiO 2; 100%，15%和12%）。纳入24例健康受试者。视网膜血流研究相结合的血管直径的测量，使用动态血管分析仪与测量的血液流速，使用激光多普勒测速仪。使用光谱反射计测量氧饱和度并计算氧提取。闪烁刺激增加视网膜血流量（57.7 ± 17.8%）和氧提取（34.6 ± 24.1%; p < 0.001）。在100%氧呼吸期间，视网膜血流和氧摄取的反应增加（均P < 0.01）。相比之下，呼吸气体混合物与12%和15%的FiO 2并没有改变闪烁诱导的视网膜血流动力学变化。目前的研究表明，在血流量相当的增加，在视网膜中的氧提取的增加大于在大脑中。在全身性高氧期间，对神经刺激的血流和氧提取反应增加。其潜在机制尚不清楚。
Cerebral and retinal blood flow are dependent on local neuronal activity. Several studies quantified the increase in cerebral blood flow and oxygen consumption during activity. In the present study we investigated the relation between changes in retinal blood flow and oxygen extraction during stimulation with diffuse luminance flicker and the influence of breathing gas mixtures with different fractions of O2 (FiO2; 100% 15% and 12%). Twenty-four healthy subjects were included. Retinal blood flow was studied by combining measurement of vessel diameters using the Dynamic Vessel Analyser with measurements of blood velocity using laser Doppler velocimetry. Oxygen saturation was measured using spectroscopic reflectometry and oxygen extraction was calculated. Flicker stimulation increased retinal blood flow (57.7 ± 17.8%) and oxygen extraction (34.6 ± 24.1%; p < 0.001 each). During 100% oxygen breathing the response of retinal blood flow and oxygen extraction was increased (p < 0.01 each). By contrast, breathing gas mixtures with 12% and 15% FiO2 did not alter flicker–induced retinal haemodynamic changes. The present study indicates that at a comparable increase in blood flow the increase in oxygen extraction in the retina is larger than in the brain. During systemic hyperoxia the blood flow and oxygen extraction responses to neural stimulation are augmented. The underlying mechanism is unknown.