PREDICTING CLEAVABILITY OF PEPTIDE SEQUENCES BY HIV PROTEASE VIA CORRELATION-ANGLE APPROACH
PREDICTING CLEAVABILITY OF PEPTIDE SEQUENCES BY HIV PROTEASE VIA CORRELATION-ANGLE APPROACH
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DOI：
10.1007/bf01028191
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发表时间：
1993-06-01
期刊：
影响因子：
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通讯作者：
CHOU, JJ
中科院分区：
文献类型：
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作者：
CHOU, JJ
在设计艾滋病毒蛋白酶抑制剂作为艾滋病治疗的潜在药物时，了解多蛋白中的哪些肽序列可被艾滋病毒蛋白酶切割是非常有用的。本文基于任何八肽都可以唯一表达为160维向量的表述以及任意两个八肽向量的相似性与其相关角相关的原理，提出了一种预测HIV-1和HIV-2蛋白酶对肽序列的裂解性的新方法，该方法对已知HIV-1蛋白酶裂解性的105个肽序列的平均预测准确度为96/105 = 9.14%，比现有方法对同组数据的计算结果提高了约8%。当使用新方法预测某些蛋白质中的HIV-2蛋白酶切割位点时，也获得了相当高的预测正确率。
In designing HIV protease inhibitors as potential drugs for AIDS therapy, knowledge about what peptide sequences in polyproteins are cleavable by HIV proteases is very useful. In this article, based on the formulation that any octapeptide can be uniquely expressed as a 160-dimensional vector and the principle that the similarity of any two such vectors is associated with their correlation angle, a new method is proposed to predict the cleavability of a peptide sequence by HIV-1 and HIV-2 proteases, The average predicted accuracy the new method for the 105 peptide sequences whose cleavability by HIV-1 protease is known is 96/105 = 9.14%, which is about 8% higher than that by the existing method for the same set of data. A considerably high rate of correct prediction was also obtained when the new method was used to predict the HIV-2 protease-cleaved sites in some proteins.