Ambulatory blood pressure nondipping status in salt-sensitive and salt-resistant black adolescents.
Ambulatory blood pressure nondipping status in salt-sensitive and salt-resistant black adolescents.
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盐敏感和耐盐黑人青少年的动态血压非下降状态。
DOI：
10.1016/s0895-7061(98)00234-9
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发表时间：
1999
影响因子：
3.2
通讯作者：
Miller,SB
中科院分区：
文献类型：
--
作者：
Wilson,DK;Sica,DA;Miller,SB
本研究调查了53名健康黑人青少年盐敏感性与动态血压的关系。盐敏感性定义为从5天低盐饮食（50 mmol/24 h）到10天高盐饮食（150 mmol/24 h NaCl补充剂）的平均血压升高大于或超过5 mm Hg。16名受试者为盐敏感型，37名受试者为耐盐型（平均血压升高5 mm Hg）。根据受试者的24小时动态血压值，将其归类为杓型（从清醒到入睡血压降低≥10%）。非杓型血压者的收缩压、舒张压和平均睡眠血压均高于杓型血压者（P<0.05）。盐敏感者的日间舒张压和平均血压高于盐抵抗者（P<0.05）。在舒张压（P<0.001）和平均血压（P<0.05）方面，非勺型者对盐敏感的比例显著高于盐抵抗者。对于这两项血压测量，50%的盐敏感受试者处于非浸入状态，而耐盐受试者的舒张压仅为5.4%，平均血压为18.9%。这些结果首次表明，在血压正常的黑人青少年人群中，盐敏感性与非杓型血压状态相关。Am J Hypertens 1999;12：159-165 © 1999 American Journal of Hypertension，Ltd.
This study examined the relationship between salt sensitivity and ambulatory blood pressure in 53 healthy black adolescents. Salt sensitivity was defined as an increase in mean blood pressure greater than or exceeding 5 mm Hg from a 5-day low-salt diet (50 mmol/24 h) to a 10-day high-salt diet (150 mmol/24 h NaCl supplement). Sixteen subjects were salt sensitive and 37 subjects were salt resistant (showed 5 mm Hg increase in mean blood pressure). Subjects were classified as dippers (≥10% decrease in blood pressure from awake to asleep) based on their 24-h ambulatory blood pressure values. Nondippers showed higher systolic, diastolic, and mean asleep blood pressures than dippers (P<.05 for all). Salt-sensitive subjects showed greater daytime diastolic and mean blood pressures than salt-resistant subjects (P<.05 for both). A significantly greater percentage of nondippers were salt sensitive, compared with salt resistant for diastolic blood pressure (P<.001) and mean blood pressure (P<.05). For both of these blood pressure measures, 50% of the salt-sensitive subjects had a nondipping status, compared with only 5.4% of the salt-resistant subjects for diastolic blood pressure, and 18.9% of the salt-resistant subjects for mean blood pressure. These results are the first to indicate that salt sensitivity is associated with nondipper blood pressure status in a black normotensive adolescent population. Am J Hypertens 1999;12:159–165 © 1999 American Journal of Hypertension, Ltd.
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DOI：
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期刊：
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影响因子：
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