Nonmineralized and mineralized compartments of bone: the role of pyridinoline in nonmineralized collagen.
Nonmineralized and mineralized compartments of bone: the role of pyridinoline in nonmineralized collagen.
复制标题
骨的非矿化和矿化区室：吡啶啉在非矿化胶原蛋白中的作用。
DOI：
10.1016/0006-291x(83)91094-x
复制
发表时间：
1983
影响因子：
3.1
通讯作者：
Mechanic,GL
中科院分区：
文献类型：
--
作者：
Banes,AJ;Yamauchi,M;Mechanic,GL
从骨干骨的非矿化和矿化区室获得的胶原蛋白胰蛋白酶肽具有不同的分子间交联分布。吡啶啉，一种被认为与年代较老的骨相关的胶原交联，在来自正常矿化胶原的肽中检测到，但在来自矿化胶原的肽中未检测到。矿化可能会阻止胶原蛋白的成熟，相反，非矿化胶原蛋白中的吡啶啉可能会减少原纤维中胶原蛋白链之间的分子间距离，并阻止矿化。
Collagen tryptic peptides obtained from the nonmineralized and mineralized compartments of diaphyseal bone have different distributions of intermolecular crosslinks. Pyridinoline, a collagen crosslink thought to be associated with chronologically older bone, was detected in peptides from normineralized collagen but not from mineralized collagen. Mineralization may prevent collagen maturation; conversely, pyridinoline in nonmineralized collagen may decrease the intermolecular distances among collagen chains in fibrils and preclude mineralization.