Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications
Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications
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DOI：
10.1016/j.sna.2005.10.001
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发表时间：
2006-01-26
影响因子：
4.6
通讯作者：
Wang, SX
中科院分区：
文献类型：
--
作者：
Li, GX;Sun, SH;Wang, SX
我们提出了巨磁阻（GMR）自旋阀传感器，设计用于超顺磁性纳米颗粒的检测，作为磁性生物检测技术中潜在的生物分子标记。我们讨论了传感器的设计，并通过实验证明，在室温下，亚微米自旋阀传感器可以检测到多达23个单分散的16纳米超顺磁性Fe3O4纳米颗粒，而无需求助于锁定检测。基于聚合物介导过程和精细光刻技术，开发了一种用于检测的纳米颗粒自组装方法。结果表明，传感器信号随纳米粒子数量的增加呈线性增加。(C) 2005 Elsevier B.V.版权所有
We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as similar to 23 monodisperse 16-nm superparamagnetic Fe3O4 nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in detection. A patterned self-assembly method of nanoparticles, based on a polymer-mediated process and fine lithography, is developed for the detection. It is found that sensor signal increases linearly with the number of nanoparticles. (C) 2005 Elsevier B.V. All rights reserved.