Sickle cell disease: Reducing the global disease burden
Sickle cell disease: Reducing the global disease burden
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DOI：
10.1111/ijlh.13023
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发表时间：
2019-05-01
影响因子：
3
通讯作者：
Odame, Isaac
中科院分区：
文献类型：
--
作者：
Mburu, Joy;Odame, Isaac
镰状细胞病在很大程度上是一个无形的全球健康问题，特别是在高发病率地区，主要是由于当地卫生政策制定者和公众缺乏认识。公共卫生干预措施，如新生儿筛查、预防细菌感染和肺炎球菌感染的免疫接种，可以产生最大的影响。家庭教育的评估脾脏大小和随后的检测脾隔离症和不情愿寻求医疗照顾的发热儿童也很重要的发病率和死亡率的控制与SCD儿童生活在资源贫乏的国家。除了这些负担得起的干预措施，羟基脲治疗是必要的，以减少镰状细胞贫血的急性和慢性并发症。镰状细胞病已被确认为具有全球健康意义的主要机构，包括世界卫生组织在2006年和联合国在2008年。2010年，世界卫生组织发布了国家卫生保健管理目标，并为撒哈拉以南非洲国家制定了控制和管理SCD的目标。这些尚未转化为行动。要做到这一点，就需要在这些地区建立积极和可持续的公私伙伴关系，以促进可持续方案的发展。有效的干预措施应纳入现有的卫生系统，最好的例子是将初级卫生保健设施与区域和三级卫生保健机构的专门镰状细胞病中心联系起来。
Sickle cell disease has been largely an invisible global health issue, especially in regions of high incidence mainly due to lack of awareness among both the local health policy makers and the public. Public health interventions, such as screening of newborns, provision of prophylaxis against bacterial infections, and immunizations against pneumococcal infections can have the greatest impact. Family education on assessment of spleen size and subsequent detection of splenic sequestration and promptness to seek medical attention for a febrile child is also important in the control of the morbidity and mortality of children with SCD living in resource-poor countries. In addition to these affordable interventions, hydroxyurea therapy is necessary to decrease both the acute and chronic complications of sickle cell anemia. Sickle cell disease has been recognized to have global health significance by key institutions including the World Health Organization in 2006 and the United Nation is 2008. In 2010, the WHO released national health care management goals and set targets to be achieved by the countries in sub-Saharan Africa for the control and management of SCD. These are yet to be translated into action. To do, this would require active and sustainable public-private partnerships for sustainable program development in these regions. Effective interventions should be integrated into existing health systems, the best examples linking primary healthcare facilities to specialized sickle cell disease centers in regional and tertiary healthcare institutions.