Association between irritability and bias in attention orienting to threat in children and adolescents
Association between irritability and bias in attention orienting to threat in children and adolescents
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DOI：
10.1111/jcpp.12659
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发表时间：
2017-05-01
影响因子：
7.6
通讯作者：
Leibenluft, Ellen
中科院分区：
文献类型：
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作者：
Salum, Giovanni A.;Mogg, Karin;Leibenluft, Ellen
背景烦躁是精神疾病儿童的常见症状，反映了他们更易发怒。在儿科临床样本的初步工作联系易怒的注意力偏差的威胁，目前的研究探讨这种关联在一个大的人口为基础的sample.MethodsWe研究了1,872名儿童（6-14岁）使用的发展和幸福感评估（DAWBA），儿童行为检查表（CBCL），和点探测任务。使用评估发脾气和火爆脾气的CBCL项目定义易怒。点探测任务评估了威胁相关（愤怒的脸）刺激的注意力偏差。当调整人口统计学变量和共同发生的精神病特征时，使用多元回归分析来评估与易怒相关的特异性。倾向得分匹配分析，以增加因果推理时匹配的人口统计学变量和共同发生的精神traits.ResultsIrritability与增加注意力偏向威胁相关的线索。多元回归分析表明，易怒和威胁偏见之间的关联是独立于人口统计学变量，焦虑和外化特征（注意力缺陷/多动，行为，任性/伤害），但不是从广泛的内化症状。倾向评分匹配分析表明，这种关联被发现为易怒与nonirritable组匹配的人口统计学和共同发生的特征，包括internalizing symptoms.ConclusionsIrritability在儿童与偏见的注意力向威胁性的信息。这一发现，如果复制，值得进一步调查，以检查在何种程度上，它有助于慢性易怒，并探讨可能的治疗意义。
BackgroundIrritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample.MethodsWe studied 1,872 children (ages 6-14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits.ResultsIrritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms.ConclusionsIrritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications.