Human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis and association with HLA-DR types.
Human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis and association with HLA-DR types.
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人类白细胞抗原（HLA）对肺结核易感性的控制以及与 HLA-DR 类型的关联。
DOI：
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发表时间：
1983
影响因子：
6.4
通讯作者：
M. C. Vaidya
中科院分区：
文献类型：
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作者：
S. Singh;N. Mehra;H. B. Dingley;J. Pande;M. C. Vaidya
为了证明人类白细胞抗原（HLA）连锁控制肺结核的易感性，25个多例家庭的组织分型为I类和II类HLA特异性。还检查了8种非HLA遗传标记，以确定是否存在可能影响结核分枝杆菌感染的其他遗传因素。对同胞中估计的HLA单倍型分离的观察表明，84%的受影响同胞比正常未受影响的同胞彼此之间共享共同单倍型的频率显著高于预期（P <0.001）。此外，DR2从患病父母向患病后代的传播（27例中的21例）和从健康父母向患病后代的传播（17例中的15例）与DR2从任何一组父母向健康后代的传播（分别为15例中的6例和16例中的10例）形成对比。非HLA多态性的分离没有偏离预期的数字显着。这些数据提供了强有力的证据支持DR 2相关的肺结核易感性。
To demonstrate human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis, 25 multiple-case families were tissue typed for class I and class II HLA specificities. Eight non-HLA genetic markers were also examined for any indication of other genetic factors that might influence the Mycobacterium tuberculosis infection. Observations on estimated HLA haplotype segregation in the sibs suggest that 84% of the affected sibs shared significantly more often than expected a common haplotype with each other than the normal unaffected sibs (P less than 0.001). Also, there was a skewed transmission of DR2 to diseased offspring from diseased parents (21 of 27) and to diseased offspring from healthy parents (15 of 17) in contrast to the transmission of DR2 from either group of parents to healthy offspring (six of 15 and 10 of 16, respectively). The segregation of non-HLA polymorphisms did not deviate significantly from the expected figures. These data provide strong evidence in favor of DR2-associated susceptibility to pulmonary tuberculosis.