Galvanic vestibular stimulation counteracts hypergravity-induced plastic alteration of vestibulo-cardiovascular reflex in rats
Galvanic vestibular stimulation counteracts hypergravity-induced plastic alteration of vestibulo-cardiovascular reflex in rats
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DOI：
10.1152/japplphysiol.00400.2009
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发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Morita, Hironobu
中科院分区：
文献类型：
--
作者：
Abe, Chikara;Tanaka, Kunihiko;Morita, Hironobu
田中平，张建平，张建平，等。前庭电刺激对大鼠前庭-心血管反射的影响。中国生物医学工程学报（英文版），2009；首次发表于2009年8月13日；doi: 10.1152 / japplphysiol.00400.2009。-我们实验室最近的数据表明，当大鼠在超重力环境中长大时，前庭-心血管反射的敏感性降低。在超重力环境中，前庭系统的静态输入增加；然而，由于日常活动减少，前庭系统的相位输入可能减少。这种减少可能导致前庭-心血管反射的使用依赖性可塑性。因此，我们假设前庭电刺激（GVS）可能补偿前庭系统相位输入的减少，从而保留前庭-心血管反射。为了验证这一假设，我们测量了大鼠在1-G或3-G环境下的水平和垂直运动，作为前庭系统相位输入的指标。然后，我们将大鼠在有或没有GVS的3g环境中饲养6天，测量压力对线性加速度的反应，以检查前庭-心血管反射的敏感性。3-G大鼠水平和垂直运动明显少于1-G大鼠。3-G大鼠对向前加速的压力反应也明显较低（1- g大鼠23 +/- 1 mmHg， 3-G大鼠12 +/- 1 mmHg）。在GVS （20 +/- 1 mmHg）的3-G大鼠中，升压反应保持不变。GVS刺激前庭内侧核Fos表达。这些结果表明，GVS刺激前庭初级神经元，并防止超重引起的前庭-心血管反射敏感性下降。
Abe C, Tanaka K, Awazu C, Morita H. Galvanic vestibular stimulation counteracts hypergravity-induced plastic alteration of vestibulo-cardiovascular reflex in rats. J Appl Physiol 107: 1089-1094, 2009. First published August 13, 2009; doi:10.1152/japplphysiol.00400.2009.-Recent data from our laboratory demonstrated that, when rats are raised in a hypergravity environment, the sensitivity of the vestibulo-cardiovascular reflex decreases. In a hypergravity environment, static input to the vestibular system is increased; however, because of decreased daily activity, phasic input to the vestibular system may decrease. This decrease may induce use-dependent plasticity of the vestibulo-cardiovascular reflex. Accordingly, we hypothesized that galvanic vestibular stimulation (GVS) may compensate the decrease in phasic input to the vestibular system, thereby preserving the vestibulo-cardiovascular reflex. To examine this hypothesis, we measured horizontal and vertical movements of rats under 1-G or 3-G environments as an index of the phasic input to the vestibular system. We then raised rats in a 3-G environment with or without GVS for 6 days and measured the pressor response to linear acceleration to examine the sensitivity of the vestibulo-cardiovascular reflex. The horizontal and vertical movement of 3-G rats was significantly less than that of 1-G rats. The pressor response to forward acceleration was also significantly lower in 3-G rats (23 +/- 1 mmHg in 1-G rats vs. 12 +/- 1 mmHg in 3-G rats). The pressor response was preserved in 3-G rats with GVS (20 +/- 1 mmHg). GVS stimulated Fos expression in the medial vestibular nucleus. These results suggest that GVS stimulated vestibular primary neurons and prevent hypergravity-induced decrease in sensitivity of the vestibulo-cardiovascular reflex.