Socio-economic level, farming activities and risk of cancer in small areas of Southern Spain
Socio-economic level, farming activities and risk of cancer in small areas of Southern Spain
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DOI：
10.1023/b:ejep.0000036808.26094.43
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发表时间：
2004-07-01
影响因子：
13.6
通讯作者：
Daponte, A
中科院分区：
文献类型：
--
作者：
Ocaña-Riola, R;Sánchez-Cantalejo, C;Daponte, A
一项生态设计被用来研究西班牙南部癌症发病率与社会经济和环境特征的关系。对1985-1996年诊断的24个部位和26380例病例进行了分析。数据分析采用广义加性模型。除唇癌外，城市地区所有地点的癌症风险都有所增加。城乡居民患非黑色素瘤的相对危险度为1.09(95%CI：1.00-1.18)，患宫颈癌的相对危险度为1.64(95%CI：1.28-2.12)。高、低失业率地区的相对危险度分别为：胃癌1.29(95%CI：1.07~1.57)、口腔癌1.45(95%CI：1.10~1.93)、食道癌1.77(95%CI：1.02~3.05)。失业率最高的地区黑色素瘤发病率最低。在文盲得分最高的城市，罹患白血病、胆囊癌、乳腺癌和前列腺癌的风险显著下降了约28%。高比例的耕地与子宫癌、喉癌、直肠癌、肺癌、皮肤非黑色素瘤和脑癌有关。对于这些部位，风险显著增加了23%(皮肤非黑色素瘤)到70%(直肠)。高集约化农业的地区患唇癌、口腔癌、喉癌、食道癌、结肠癌、肺癌和膀胱癌的风险显著增加。结肠癌的相对危险度为1.16(95%CI：1.04-1.29)，食道癌的相对危险度为1.47(95%CI：1.15-1.87)。这项研究的结果表明，社会经济和环境因素对于分析西班牙南部小地区的癌症发病率有多么重要。
An ecological design was used to study the relationship between cancer incidence and both socioeconomic and environmental features in Southern Spain. Twenty-four sites and 26,380 cases diagnosed in 1985-1996 were analysed. Generalised Additive Models were used for data analysis. Except for lip cancer, the urban areas showed an increase in cancer risk for all sites. The relative risks among urban and rural municipalities ranges between 1.09 for skin non-melanoma (95% CI: 1.00-1.18) and 1.64 for cervix cancer (95% CI: 1.28-2.12). The relative risk among areas with high and low unemployment was 1.29 for stomach cancer (95% CI: 1.07-1.57), 1.45 for oral cavity cancer (95% CI: 1.10-1.93) and 1.77 for oesophagus cancer (95% CI: 1.02-3.05). Areas with highest unemployment showed the lowest incidence of melanoma. Risk for leukaemia, gall bladder, breast and prostate cancer showed a significant decreases by approximately 28% in the municipalities with the highest illiteracy score. A high percentage of land under cultivation was related to uterine tumours, larynx, rectum, lung, skin non-melanoma and brain cancers. For these sites, the risk had a significant increase by between 23% (skin non-melanoma) and 70% ( rectum). Areas with high intensive farming showed a significant increase in cancer risk for lip, oral cavity, larynx, oesophagus, colon, lung, and bladder cancer. The relative risks ranges between 1.16 for colon cancer (95% CI: 1.04-1.29) and 1.47 for oesophagus cancer (95% CI: 1.15-1.87). The results of this study reveal how important socio-economic and environmental factors are for the analysis of cancer incidence in small areas of Southern Spain.