Changes in the Pattern of Respiratory Diseases Necessitating Hospitalization of HIV-infectedPatients Since the Advent of Highly Active Antiretroviral Therapy
Changes in the Pattern of Respiratory Diseases Necessitating Hospitalization of HIV-infectedPatients Since the Advent of Highly Active Antiretroviral Therapy
复制标题
自高效抗逆转录病毒疗法出现以来，艾滋病毒感染者需要住院治疗的呼吸道疾病模式的变化
作者：
V. Dufour;J. Cadranel;M. Wislez;A. Lavolé;E. Bergot;A. Parrot;P. Rufat;C. Mayaud
自从采用高效抗逆转录病毒疗法以来，机会性疾病的发病率、住院率和死亡率都显著下降。我们研究了高效抗逆转录病毒疗法对需要住院治疗的HIV相关呼吸道疾病模式的影响。我们回顾性地比较了法国广泛使用HAART处方前三年（第1时代，从1993年7月开始）和前三年期间在巴黎大学医院胸科住院的艾滋病毒感染患者中诊断出的呼吸道疾病的数量和病因。广泛使用HAART处方的三年（第2时代，从1996年7月开始）。在第一阶段和第二阶段，分别有207名和119名艾滋病毒感染者因呼吸道疾病入院。在第2阶段，只有31.1%的患者接受了HAART治疗。除卡氏肺孢子虫肺炎（PCP）（p = 0.0008）和革兰氏阴性杆菌引起的慢性支气管疾病加重（p = 0.04）以外的肺部机会性感染在第2期几乎消失。相比之下，PCP、细菌性肺炎、肺结核、肺卡波西肉瘤和肺非霍奇金淋巴瘤在第2代仅显示出2倍的下降，而肺癌更常见（p = 0.004）。自高效抗逆转录病毒疗法问世以来，艾滋病毒感染者因严重呼吸道疾病而需要住院治疗的频率有所下降，其病原学分布也发生了变化。
The incidence rates of opportunistic diseases, hospital admission and death have fallen markedly since the advent of highly active antiretroviral therapy (HAART). We examined the impact of HAART on the pattern of HIV-related respiratory diseases necessitating hospitalization. We retrospectively compared the numbers and etiologies of respiratory diseases diagnosed in HIV-infected patients hospitalized in the chest department of a Paris university hospital during the three years preceding widespread prescription of HAART in France (era 1, starting in July 1993) and the first three years of widespread HAART prescription (era 2, starting in July 1996). Respectively, 207 and 119 HIV-infected patients were admitted for respiratory disease in era 1 and era 2. Only 31.1% of patients admitted during era 2 were receiving HAART. Pulmonary opportunistic infections other than Pneumocystis carinii pneumonia (PCP) (p = 0.0008) and exacerbations of chronic bronchial disease due to gram-negative bacilli (p = 0.04) virtually disappeared in era 2. In contrast, PCP, bacterial pneumonia, tuberculosis, pulmonary Kaposi’s sarcoma and pulmonary non-Hodgkin lymphoma showed only a twofold decrease in era 2, while lung cancer was more frequent (p = 0.004). The frequency of severe respiratory diseases necessitating hospitalization of HIV-infected patients has fallen since the advent of HAART, and their etiologic distribution has changed.
有效的抗逆转录病毒治疗对 HIV-1 感染者中卡波西肉瘤和非霍奇金淋巴瘤发病率的影响。
DOI：
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发表时间：
1999
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
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作者：
Jacobson,LP;Yamashita,TE;Detels,R;Margolick,JB;Chmiel,JS;Kingsley,LA;Melnick,S;Muñoz,A
通讯作者：
Muñoz,A
抗逆转录病毒治疗对晚期 HIV 感染患者细菌性肺炎发生率的影响。
DOI：
10.1164/ajrccm.162.1.9904101
发表时间：
2000
期刊：
American journal of respiratory and critical care medicine.
影响因子：
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作者：
Sullivan,JH;Moore,RD;Keruly,JC;Chaisson,RE
通讯作者：
Chaisson,RE