Modeling postnatal exposures and their interactions with birth size
Modeling postnatal exposures and their interactions with birth size
复制标题
DOI：
10.1093/jn/134.1.201
复制
发表时间：
2004-01-01
影响因子：
4.2
通讯作者：
Cole, TJ
中科院分区：
文献类型：
--
作者：
Cole, TJ
成人疾病的胎儿起源假说认为，出生体重和后来的不良后果之间的负相关反映了胎儿编程增加了以后疾病的风险。然而，低出生体重与出生后的追赶有关，体重增加本身就是后期疾病的风险因素。这是很难解开的。体重的大小和生长成分对结果的影响随时间而变化。本文介绍了一种同时显示大小效应和生长效应的装置——生命历程图。它基于对各种权重结果的多元回归分析，以z分数表示，并且该图显示了针对相应测量年龄绘制的系数。来自巴西（佩洛塔斯）和菲律宾（宿务）的例子将青春期的血压与童年时期的体重联系起来。它们在婴儿期显示出小的反向体重效应，但早期体重的重要性不如青春期体重和体重增加。此外，宿雾研究中的出生长度影响青春期体重和血压之间关系的强度。这表明了一种胎儿计划效应，出生时间相对较长的孩子在15岁时血压和体重之间的关系更为敏感。这是好事还是坏事，目前还不清楚。
The fetal origins of adult disease hypothesis postulates that the inverse association between birth weight and later adverse outcome reflects fetal programming that increases the risk of later disease. However, low birth weight is associated with catch-up after birth, and weight gain is itself a risk factor for later disease. It is difficult to disentangle. the effects on outcome of the size and growth components of weight change through time. This paper presents the life course plot, a device to display both size and growth effects simultaneously. It is based on the multiple-regression analysis of the outcome on the various weights, expressed as z-scores, and the plot displays the coefficients plotted against the corresponding ages of measurement. Examples from Brazil (Pelotas) and the Philippines (Cebu) relate blood pressure in adolescence to weight through childhood. They show small inverse weight effects in infancy, but early weight is less important than weight and weight gain during adolescence. In addition, birth length in the Cebu study affects the strength of the relationship between weight and blood pressure in adolescence. This suggests a fetal programming effect, with children who were relatively long at birth having a more sensitive relationship between blood pressure and weight at age 15. Whether this is a good or a bad thing is not immediately clear.