Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity
Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity
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DOI：
10.1038/s41385-020-0263-0
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发表时间：
2020-02-10
影响因子：
8
通讯作者：
Hase, Koji
中科院分区：
文献类型：
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作者：
Nakamura, Yutaka;Mimuro, Hitomi;Hase, Koji
感染性结肠炎是世界上最常见的健康问题之一。微折叠（M）细胞主动转运管腔抗原至肠道相关淋巴组织以诱导伊加应答;然而，尚不清楚M细胞是否有助于诱导细胞免疫应答。在这里，我们报告说，M细胞依赖的抗原转运中起着至关重要的作用，在诱导的Th 1，Th 17，和Th 22的反应，在稳定状态下对肠道寄生虫。建立肠道特异性细胞免疫是预防肠道致病性枸橼酸杆菌感染过程中细菌传播的前提。因此，无M细胞的小鼠发展为严重的结肠炎，细菌传播增加。这种异常与粘膜屏障功能障碍有关。这些观察结果表明，由M细胞的抗原转运可能有助于维持肠道免疫稳态，引发抗原特异性细胞免疫反应。
Infectious colitis is one of the most common health issues worldwide. Microfold (M) cells actively transport luminal antigens to gut-associated lymphoid tissue to induce IgA responses; however, it remains unknown whether M cells contribute to the induction of cellular immune responses. Here we report that M cell-dependent antigen transport plays a critical role in the induction of Th1, Th17, and Th22 responses against gut commensals in the steady state. The establishment of commensal-specific cellular immunity was a prerequisite for preventing bacterial dissemination during enteropathogenic Citrobacter rodentium infection. Therefore, M cell-null mice developed severe colitis with increased bacterial dissemination. This abnormality was associated with mucosal barrier dysfunction. These observations suggest that antigen transport by M cells may help maintain gut immune homeostasis by eliciting antigen-specific cellular immune responses.