Defective Porous Carbon Polyhedra Decorated with Copper Nanoparticles for Enhanced NIR-Driven Photothermal Cancer Therapy
Defective Porous Carbon Polyhedra Decorated with Copper Nanoparticles for Enhanced NIR-Driven Photothermal Cancer Therapy
复制标题
用铜纳米颗粒装饰的有缺陷的多孔碳多面体用于增强近红外驱动的光热癌症治疗
DOI：
10.1002/smll.201905184
复制
发表时间：
2019-12-01
期刊：
影响因子：
13.3
通讯作者：
Zhou, Shuyun
中科院分区：
文献类型：
--
作者：
Weng, Yangziwan;Guan, Shanyue;Zhou, Shuyun
目前，人们对发现用于近红外（NIR）驱动的癌症治疗的新的和改进的光热剂有极大的兴趣。本文中，通过在氩气气氛下在400-900摄氏度范围内的不同温度（t）下加热Cu-BTC金属有机骨架（MOF）前体，成功地制备了一系列新型光热剂，其包含负载在有缺陷的多孔碳多面体上的铜纳米颗粒。所得产物中的铜纳米颗粒尺寸和碳缺陷浓度（在本文中表示为Cu@CPP-t）随着合成温度而增加，从而赋予Cu@CPP-t样品不同的NIR吸收性质和光热加热响应。在808 nm激光照射下，Cu@CPP-800样品显示出48.5%的显著光热转换效率，代表了碳基光热剂迄今报道的最高光热效率之一。用荷瘤裸Balb/c小鼠进行的体内实验证实了Cu@CPP-800作为用于癌症治疗的非常有前途的NIR驱动的光疗剂的功效。结果鼓励更广泛地使用MOF作为低成本的前体，用于合成用于光热治疗的碳支撑的金属纳米颗粒复合材料。
Currently, there is tremendous interest in the discovery of new and improved photothermal agents for near-infrared (NIR)-driven cancer therapy. Herein, a series of novel photothermal agents, comprising copper nanoparticles supported on defective porous carbon polyhedra are successfully prepared by heating a Cu-BTC metal-organic framework (MOF) precursor at different temperatures (t) in the range 400-900 degrees C under an argon atmosphere. The copper nanoparticle size and carbon defect concentration in the obtained products (denoted herein as Cu@CPP-t) increase with synthesis temperature, thus imparting the Cu@CPP-t samples with distinct NIR absorption properties and photothermal heating responses. The Cu@CPP-800 sample shows a remarkable photothermal conversion efficiency of 48.5% under 808 nm laser irradiation, representing one of the highest photothermal efficiencies yet reported for a carbon-based photothermal agent. In vivo experiments conducted with tumor bearing nude Balb/c mice confirm the efficacy of Cu@CPP-800 as a very promising NIR-driven phototherapy agent for cancer treatment. Results encourage the wider use of MOFs as low cost precursors for the synthesis of carbon-supported metal nanoparticle composites for photothermal therapy.