Validated assay for the quantification of anastrozole in human plasma by capillary gas chromatography Ni-63 electron capture detection
Validated assay for the quantification of anastrozole in human plasma by capillary gas chromatography Ni-63 electron capture detection
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DOI：
10.1016/s0378-4347(97)00129-1
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发表时间：
1997-10-24
期刊：
影响因子：
--
通讯作者：
Dyroff, M
中科院分区：
文献类型：
--
作者：
Bock, MJH;Bara, I;Dyroff, M
An assay was developed for the quantification of anastrozole [2,2'-[5-(1H-1,2,4-triazol-1-ymethyl)-1,3-phenylene]bis(2-methylpropiononitrile)] in human plasma using liquid-liquid extraction. Anastrozole and an internal standard chromatographed and detected by gas chromatography with electron capture detection, using a combination temperature-pressure program. The range of the assay is 3 to 100 ng/ml. Anastrozole was quantified by comparing its peak area to that of an internal standard. A cross-validation of this assay was also successfully performed between several laboratories. (C) 1997 Elsevier Science B.V.
