Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing.
Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing.
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DOI：
10.1002/ccr3.270
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发表时间：
2015-06
影响因子：
0.7
通讯作者：
Shiraki, Kimiyasu
中科院分区：
文献类型：
--
作者：
Daikoku, Tohru;Oyama, Yukari;Yajima, Misako;Sekizuka, Tsuyoshi;Kuroda, Makoto;Shimada, Yuka;Takehara, Kazuhiko;Miwa, Naoko;Okuda, Tomoko;Sata, Tetsutaro;Shiraki, Kimiyasu
单纯疱疹病毒2型引起生殖器溃疡，在阿昔洛韦治疗期间出现继发性疱疹whitlow。与生殖器分离物相比，继发性和复发性whitlow分离物具有无环韦抗性和温度敏感性。我们通过深度测序分析确定了导致温度敏感性的核糖核苷酸还原酶突变。
Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation responsible for temperature-sensitivity by deep-sequencing analysis.