Phenolic Constituents of Acorus gramineus
Phenolic Constituents of Acorus gramineus
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DOI：
10.1007/s12272-011-0808-6
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发表时间：
2011-08-01
影响因子：
6.7
通讯作者：
Lee, Kang Ro
中科院分区：
文献类型：
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作者：
Park, Cheol Hyeong;Kim, Ki Hyun;Lee, Kang Ro
使用柱色谱法纯化石菖蒲（天南星科）根茎中的甲醇提取物，得到两种新的苯丙素立体异构体：acoraminol A (1) 和 acoraimol B (2)。还提供了17种已知的酚类化合物，β-细辛脑(3)、细辛醛(4)、异辛香酮(5)、丙哌拉酮(6)、(1'R,2'S)-1',2'-二羟基细辛脑(7)、(1'S,2'S)-1',2'-二羟基细辛脑(8)、3',4'-二甲氧基肉桂醇(9)、 3',4',5'-三甲氧基肉桂醇(10)、山奈酚3-甲基醚(11)、2-[4-(3-羟丙基)-2-甲氧基苯氧基]-1,3-丙二醇(12)、羟基酪醇(13)、酪醇(14)、(2S,5S)-二藜芦基-(3R,4S)-二甲基四氢呋喃(15)、(7S,8R)-二氢脱氢二松树醇(16)、7S,8S-苏-4,7,9,9'-四羟基-3,3'-二甲氧基-8-O-4'-新木脂素(17)、 7S,8R-赤式-4,7,9,9'-四羟基-3,3'-二甲氧基-8-O-4'-新木脂素 (18) 和二氢yashsbushiketol (19)。通过分析光谱数据（包括一维和二维核磁共振数据）阐明了新化合物的结构。 1 和 2 的绝对构型是使用方便的 Mosher 酯程序确定的。化合物5-19 首次从该植物来源中分离出来。使用 Sulforhodamine B (SRB) 生物测定法在体外测试了分离的化合物对四种人类肿瘤细胞系的细胞毒性。
The purification of a MeOH extract from the rhizome of Acorus gramineus (Araceae) using column chromatography furnished two new stereoisomers of phenylpropanoid, acoraminol A (1) and acoraimol B (2). It also furnished 17 known phenolic compounds, beta-asarone (3), asaraldehyde (4), isoacoramone (5), propioveratrone (6), (1'R,2'S)-1',2'-dihydroxyasarone (7), (1'S,2'S)-1',2'-dihydroxyasarone (8), 3',4'-dimethoxycinnamyl alcohol (9), 3',4',5'-trimethoxycinnamyl alcohol (10), kaempferol 3-methyl ether (11), 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol (12), hydroxytyrosol (13), tyrosol (14), (2S,5S)-diveratryl-(3R,4S)-dimethyltetrahydrofuran (15), (7S,8R)-dihydrodehydrodiconiferyl alcohol (16), 7S,8S-threo-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan (17), 7S,8R-erythro-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan (18), and dihydroyashsbushiketol (19). The structures of the new compounds were elucidated by analysis of spectroscopic data including 1D and 2D NMR data. The absolute configurations of 1 and 2 were determined using the convenient Mosher ester procedure. Compounds 5-19 were isolated for the first time from this plant source. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamine B (SRB) bioassay.