Correlation between overactive bladder symptom score and neuropsychological parameters in Alzheimer's disease patients with lower urinary tract symptom.
Correlation between overactive bladder symptom score and neuropsychological parameters in Alzheimer's disease patients with lower urinary tract symptom.
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DOI：
10.1590/s1677-5538.ibju.2015.0664
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
Park MH
中科院分区：
文献类型：
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作者：
Jung HB;Choi DK;Lee SH;Cho ST;Na HR;Park MH
研究膀胱过度活动症症状评分（OABSS）和神经心理学参数之间的关系。此外，我们还调查了影响问卷中每个项目的因素。 共招募了376例可能患有阿尔茨海默病（AD）的患者（男性：184例;女性：192例）。采用简易精神状态检查（MMSE）、临床痴呆评定（CDR）量表、总体恶化量表（GDS）和Barthel日常生活活动（ADL）进行认知测试。采用OABSS和排尿日记评估下尿路症状（LUTS）。 AD患者中膀胱过度活动症（OAB）（定义为OABSS ≥3，尿急评分≥2）的患病率为72.6%。在OAB受试者中，最常见的症状严重程度为中度（72.6%），其次为轻度（21.2%）和重度（5.8%）。OABSS与增龄有很高的相关性（r=0.75; p<0.001）。与神经心理学参数比较，OABSS与CDR评分高度相关（r=0.446; p<0.001）。但OABSS评分的变化与其他神经心理学指标的变化无显著相关性。根据个体症状评分，急迫性尿失禁与CDR评分高度相关（r=0.43; p<0.001）。 OABSS是评估AD患者LUTS的有用工具。OABSS严重程度（包括急迫性尿失禁）与CDR评分之间存在一致的正相关性。
To examine an association between the overactive bladder symptom score (OABSS) and neuropsychological parameters. Moreover, we investigate the factors that affect each item in the questionnaire. A total of 376 patients (males: 184; females: 192) with probable Alzheimer’s disease (AD) were recruited. Cognitive testing was conducted using the Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR) scale, Global Deterioration Scale (GDS), and Barthel Activities of Daily Living (ADL). Lower urinary tract symptom (LUTS) was assessed using OABSS and voiding diary. The prevalence of overactive bladder (OAB) (defined as OABSS ≥3 with an urgency score of ≥2) in patients with AD was 72.6%. Among the OAB subjects, the most common severity of symptom was moderate (72.6%), followed by mild (21.2%), and severe (5.8%). It was found that OABSS had a very high correlation with aging (r=0.75; p<0.001). When compared with neuropsychological parameters, it was found that OABSS was highly correlated with the CDR scores (r=0.446; p<0.001). However, no significant correlation was found between the changes in OABSS scores and those in other neuropsychological parameters. Based on the individual symptom scores, urgency incontinence was highly correlated with the CDR scores (r=0.43; p<0.001). OABSS is a useful tool in assessing AD patients with LUTS. There was a consistent positive association between OABSS severity, including urgency incontinence, and CDR scores.