Statistical correlation of nucleotides in a DNA sequence
Statistical correlation of nucleotides in a DNA sequence
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DNA 序列中核苷酸的统计相关性
DOI：
10.1103/physreve.58.861
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发表时间：
1998-07-01
影响因子：
2.4
通讯作者：
Tsai, L
中科院分区：
文献类型：
--
作者：
Luo, LF;Lee, WJ;Tsai, L
本文综述了DNA序列中核苷酸相关性的研究方法，并通过统计分析论证了DNA序列中核苷酸相关性的两个基本性质，即核苷酸相关性在大多数DNA序列中具有短距离优势和编码序列中短距离相关性具有粗粒度的进化依赖性。并提出了相应的演化机制。利用谱分析表明，不同序列的远程碱基相关性存在较大的不均匀性。报道了三维DNA行走的一些结果。还指出了编码序列和非编码序列之间的语言差异。
We review methods in the study of nucleotide correlation in DNA sequence, and demonstrate two basic properties of the correlation through statistical analysis, namely, the short-range dominance of nucleotide correlation in most DNA sequences and the coarse-grained evolutionary dependence of the short-range correlation in coding sequences. A corresponding evolutionary mechanism is suggested. By the use of spectral analysis a large inhomogeneity in long-range base correlations for different sequences is indicated. Some results on three-dimensional DNA walks are reported. The linguistic differences between coding and noncoding sequences are also indicated.