Risk factors for Nipah virus infection among abattoir workers in Singapore
Risk factors for Nipah virus infection among abattoir workers in Singapore
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DOI：
10.1086/315443
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发表时间：
2000-05-01
影响因子：
6.4
通讯作者：
Anderson, LJ
中科院分区：
文献类型：
--
作者：
Chew, MHL;Arguin, PM;Anderson, LJ
1999年3月10日至19日期间，新加坡2个屠宰场中1个屠宰场的11名工人患上了尼帕病毒相关脑炎或肺炎，造成1人死亡。进行了一项病例对照研究，以确定感染的职业危险因素。病例患者为具有抗尼帕IgM抗体的A屠宰场工人；对照组随机选择抗尼帕IgM检测呈阴性的屠宰场A工人，所有13例患者报告与生猪接触（P = 0.01），而41例对照组中26例（63%）报告与生猪接触（P = 0.01）。1999年3月3日禁止从同时发生尼帕病毒暴发的马来西亚各州进口猪；1999年3月19日，禁止进口马来西亚猪，并关闭了屠宰场。在2月至3月期间加工的生猪中未报告异常疾病。接触活猪似乎是人感染尼帕病毒的最重要危险因素。应尽量减少与可能受感染的活猪的直接接触，以防止将这种可能致命的人畜共患病传播给人类。
During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipahvirus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti-Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM, All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P = .01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.