HLA-DR expression by high grade superficial bladder cancer treated with BCG.
HLA-DR expression by high grade superficial bladder cancer treated with BCG.
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BCG 治疗的高级别浅表性膀胱癌的 HLA-DR 表达。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
J. Smyth
中科院分区：
文献类型：
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作者：
S. Prescott;K. James;A. Busuttil;T. Hargreave;G. Chisholm;J. Smyth
采用免疫组化方法对治疗过程中获得的一系列活检组织进行评估，以评估广泛原位癌和浅表性膀胱肿瘤的膀胱内BCG治疗的局部免疫反应。主要发现是诱导尿路上皮细胞的HLA-DR表达的强烈水平，持续几个月后完成治疗。这与主要由活化的辅助性T淋巴细胞组成的膀胱壁中的单核细胞浸润相吻合。也发现了较少数量的巨噬细胞、抑制性细胞毒性T淋巴细胞和B淋巴细胞。这些新的发现证实了对BCG的炎症反应涉及免疫反应中的尿路上皮，并表明膀胱内BCG免疫治疗的成功可能是由于增强了肿瘤抗原识别。
The local immune response to intravesical BCG therapy for widespread carcinoma in situ and superficial bladder tumour was assessed using immunohistochemical methods on serial biopsies obtained during treatment. The main findings were the induction of a strong level of HLA-DR expression by urothelial cells which persisted for several months after completion of therapy. This coincided with a mononuclear cell infiltrate in the bladder wall consisting predominantly of activated helper T lymphocytes. Smaller numbers of macrophages, suppressor cytotoxic T lymphocytes and B lymphocytes were also found. These new findings confirm that the inflammatory response to BCG involves the urothelium in an immunological reaction and suggest that the success of immunotherapy with intravesical BCG may be due to enhanced tumour antigen recognition.
BCG 介导的抗肿瘤活性需要胸腺依赖性免疫反应。
DOI：
10.1016/s0022-5347(17)43909-7
发表时间：
1987
期刊：
The Journal of urology
影响因子：
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作者：
Ratliff,TL;Gillen,D;Catalona,WJ
通讯作者：
Catalona,WJ