Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.
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DOI：
10.1016/j.cmet.2016.04.011
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发表时间：
2016-05-10
期刊：
影响因子：
29
通讯作者：
Scherer PE
中科院分区：
文献类型：
--
作者：
Stern JH;Rutkowski JM;Scherer PE
在过去的几十年里，代谢研究取得了巨大的进展，建立了脂肪细胞作为调节全身营养和能量稳态的中心变阻器。在多个控制水平下操作，脂肪细胞与器官系统通信以调节基因表达、糖调节激素胞吐、酶促反应和营养流，从而平衡正能量平衡或负能量平衡的代谢需求。这些机制的鉴定具有很大的潜力，以确定治疗糖尿病和相关代谢紊乱的新靶点。在此，我们回顾了脂肪细胞在维持代谢稳态中的核心作用，强调了三个关键介质：脂联素，瘦素和脂肪酸。
Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis highlighting three critical mediators: adiponectin, leptin, and fatty acids.