Diffuse plaques in the striatum in Alzheimer disease (AD): Relationship to the striatal mosaic and selected neuropeptide markers
Diffuse plaques in the striatum in Alzheimer disease (AD): Relationship to the striatal mosaic and selected neuropeptide markers
复制标题
DOI：
10.1097/00005072-199712000-00011
复制
发表时间：
1997-12-01
影响因子：
3.2
通讯作者：
Mirra, SS
中科院分区：
文献类型：
--
作者：
Gearing, M;Levey, AI;Mirra, SS
虽然神经性斑块和弥漫性斑块通常在阿尔茨海默病(AD)的新皮质中共存，但纹状体中弥漫性斑块的优势促使我们探索纹状体特征(如纹状体马赛克)对β-淀粉样蛋白(Aβ)沉积的潜在影响。用抗Aβ抗体和甲硫氨酸脑啡肽或生长抑素抗体双重免疫组织化学方法，研究了弥漫性斑块与背侧纹状体神经肽分布的关系。这种关系在“单纯”AD病例中以及与帕金森病(PD)病理共存的AD病例中进行了研究，即黑质变性和任意部位的路易小体(AD+PD)。尽管两组均存在大量Aβ阳性弥漫性斑块，但甲硫氨酸脑啡肽免疫反应斑块所示的马赛克图案被保存下来。斑块与甲硫氨酸脑啡肽阳性斑块或生长抑素免疫反应神经元之间没有明显的联系。然而，在AD+PD中，基质中的酪氨酸羟化酶免疫反应减弱，很可能反映了这些病例的黑质变性。总体而言，这些观察表明AD患者的新纹状体Aβ沉积不受与纹状体镶嵌相关的环境因素的影响。
Although neuritic and diffuse plaques generally coexist in Alzheimer disease (AD) neocortex, the predominance of diffuse plaques in the striatum prompted us to explore the potential influence of striatal features such as the striatal mosaic on beta-amyloid (A beta) deposition. Using double immunohistochemistry with an antibody to A beta in combination with antibodies to met-enkephalin or somatostatin, we investigated the relationship between diffuse plaques and neuropeptide distribution in the dorsal striatum. This relationship was examined in "pure" AD cases as well as in AD cases with coexisting Parkinson disease (PD) pathology, i.e. nigral degeneration and Lewy bodies at any site (AD+PD). Despite the presence of numerous A beta-positive diffuse plaques in both groups, the mosaic pattern, as exemplified by met-enkephalin-immunoreactive patches, was preserved. No obvious association was observed between the plaques and met-enkephalin-positive patches or somatostatin-immunoreactive neurons. Tyrosine hydroxylase immunoreactivity in the matrix was, however, diminished in AD+PD, most Likely reflecting the nigral degeneration in these cases. Overall, these observations suggest that neostriatal A beta deposition in AD is not influenced by environmental factors associated with the striatal mosaic.