Polybrominated diphenyl ethers (PBDEs) in foodstuffs:: Human exposure through the diet
Polybrominated diphenyl ethers (PBDEs) in foodstuffs:: Human exposure through the diet
复制标题
DOI：
10.1021/jf0340916
复制
发表时间：
2003-05-07
影响因子：
6.1
通讯作者：
Casas, C
中科院分区：
文献类型：
--
作者：
Bocio, A;Llobet, JM;Casas, C
多溴联苯醚（PBDEs）被用作多种材料的阻燃剂，包括合成聚合物和纺织品。虽然在环境样本和人体组织中检测到这些化学物质，但关于人类通过饮食接触多溴二苯醚的信息很少。在本研究中，我们测定了2000年在加泰罗尼亚（西班牙）获得的一些食品样品中多溴二苯醚的浓度。对生活在西班牙这一地区的一般人群的膳食多溴二苯醚摄入量进行了估计。多溴二苯醚浓度最高的是油脂、鱼类和贝类、肉类和肉制品以及鸡蛋，而含量最低的是水果、蔬菜和块茎。成年男性多溴二苯醚的膳食摄入量为97.3纳克/天(假设未检出（ND) = 1/2检出限（LOD））或81.9纳克/天（假设ND = 0）。对这些值贡献最大的是鱼类和贝类，约占总摄入量的三分之一。四溴二苯醚和五溴二苯醚是对总多溴二苯醚贡献百分比最高的同源物。对于多溴二苯醚毒性效应最敏感的终点，目前的膳食摄入量与建议的最低观察到的不良影响水平值（1毫克/公斤/天）进行了比较，结果表明，与从食物中接触多溴二苯醚有关的安全系数超过5个数量级。
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a variety of materials, including synthetic polymers and textiles. Although these chemicals have been detected in environmental samples and human tissues, there is little information about human exposure to PBDEs through the diet. In the present study, we determined the concentrations of PBDEs in a number of food samples acquired in Catalonia (Spain) during 2000. The dietary intake of PBDEs was estimated for the general population living in this Spanish region. The highest PBDE concentrations were found in oils and fats, fish and shellfish, meat and meat products, and eggs, while the lowest levels corresponded to fruits, vegetables, and tubers. The dietary intake of PBDEs for an adult male was 97.3 ng/day (assuming not detected (ND) = 1/2 limit of detection (LOD)) or 81.9 ng/day (assuming ND = 0) The greatest contribution to these values corresponded to fish and shellfish, with approximately one-third of the total intake. TetraBDEs and pentaBDEs were the homologues showing the highest percentages of contribution to the sum of total PBDEs. The comparison of the current dietary intake with the suggested lowest observed adverse effect level value of 1 mg/kg/day for the most sensitive endpoints for toxic effects of PBDEs results in a safety factor over 5 orders of magnitude in relation to PBDE exposure from food.