Antibodies against Haemophilus influenzae type b capsular polysaccharide and tetanus toxoid before and after a booster dose of the carrier protein nine years after primary vaccination with a protein conjugate vaccine.
Antibodies against Haemophilus influenzae type b capsular polysaccharide and tetanus toxoid before and after a booster dose of the carrier protein nine years after primary vaccination with a protein conjugate vaccine.
复制标题
在初次接种蛋白缀合物疫苗九年后，在载体蛋白加强剂量之前和之后，针对 B 型流感嗜血杆菌荚膜多糖和破伤风类毒素的抗体。
DOI：
10.1097/01.inf.0000160955.26151.71
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Robbins,JohnB
中科院分区：
文献类型：
--
作者：
Claesson,BoA;Trollfors,Birger;Lagergard,Teresa;Knutsson,Nina;Schneerson,Rachel;Robbins,JohnB
对53名10岁以下儿童进行了白喉-破伤风联合疫苗（DT）加强免疫前和免疫后1个月的流感嗜血杆菌B型（HiB）荚膜多糖（CPS）和破伤风类毒素（TT）IgG抗体检测。所有儿童在3、5和12个月大时接种了DT和Hib-TT结合物疫苗。DT加强前后Hib CPS血清IgG抗体的几何平均浓度分别为4.16和4.30 μg/mL。TT IgG抗体几何平均浓度从0.09 IU/mL上升到4.58 IU/mL（P< 0.001）。在婴儿期适当间隔3次Hib-TT给药后，Hib CPS IgG水平保持远高于保护滴度9年。TT的加强剂量不影响Hib CPS抗体浓度，但诱导针对TT的显著IgG应答。
IgG antibodies against Haemophilus influenzae type b (Hib) capsular polysaccharide (CPS) and tetanus toxoid (TT) were measured for 53 children, 10 years of age, before and 1 month after a booster dose of diphtheria-tetanus vaccine (DT). All children had been vaccinated at 3, 5 and 12 months of age with DT and a Hib-TT conjugate. Geometric mean concentrations of Hib CPS serum IgG antibody were 4.16 and 4.30 μg/mL before and after the DT booster, respectively. The geometric mean concentration of TT IgG antibody increased from 0.09 IU/mL to 4.58 IU/mL (P< 0.001). Hib CPS IgG levels remained well above protective titers for 9 years after 3 doses of Hib-TT appropriately spaced in infancy. A booster dose of TT did not affect Hib CPS antibody concentrations but induced a pronounced IgG response against TT.