The dominance of the microenvironment in breast and ovarian cancer
The dominance of the microenvironment in breast and ovarian cancer
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DOI：
10.1006/scbi.2001.0417
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发表时间：
2002-04-01
影响因子：
14.5
通讯作者：
Bissell, MJ
中科院分区：
文献类型：
--
作者：
Roskelley, CD;Bissell, MJ
癌症的发展是一个多步骤的过程，在很大程度上是由遗传变化驱动的，这是众所周知的。然而，越来越清楚的是，在其出现之前，致瘤表型必须克服周围微环境的抑制作用。由于微环境是组织特异性的，每个器官中的癌症必须发展独特的策略来克服这些正常的表观遗传抑制因子。令人惊讶的是，在卵巢癌发展的最早阶段，腺体的诱导产生了一个与正常乳腺有许多共同之处的微环境。这种表型趋同可以解释为什么相似的遗传和表观遗传变化似乎在乳腺癌和卵巢癌的进展中起作用。
That cancer development is a multistep process, driven in large part by, genetic change, is well established. However, it is becoming increasingly clear that, prior to its emergence, the tumorigenic phenotype must overcome the suppressive effects of the surrounding microenvironment. Because the microenvironment is tissue-specific, cancer in each organ must develop unique strategies to overcome these normal epigenetic suppressors. Surprisingly, the induction of glandularity during the earliest stages of ovarian carcinoma development produces a microenvironment that has much in common with the normal mammary gland. This phenotypic convergence may explain why similar genetic and epigenetic changes appear to play a role in breast and ovarian tumor progression.