The calibration and validation of a phase-modulated near-infrared cerebral oximeter.
The calibration and validation of a phase-modulated near-infrared cerebral oximeter.
复制标题
相位调制近红外脑血氧计的校准和验证。
DOI：
10.1023/a:1009984204752
复制
发表时间：
1999
影响因子：
2.2
通讯作者：
Zager,E
中科院分区：
文献类型：
--
作者：
Levy,WJ;Carpenter,J;Fairman,RM;Golden,MA;Zager,E
客观的。本研究的目的是将实验性相位调制近红外 (NIR) 光谱系统测量的脑氧合与根据颈静脉氧饱和度估计的毛细血管饱和度进行比较。方法。 30 名接受颈动脉内膜切除术的患者放置了颈静脉导管，术中测量了 194 次静脉血氧饱和度。使用相位调制近红外光谱系统同时测量 754、785 和 816 nm 的光路长度。使用光具座和散射模具进行光学校准。血红蛋白饱和度是通过 NIR 测量值使用扩散理论推导的方程计算得出的。毛细血管饱和度是根据动脉和静脉饱和度计算的。结果。颈静脉饱和度范围为 41% 至 92%。使用光具座进行校准时，血红蛋白饱和度的 NIR 估计值与毛细管估计值的平均偏差分别为 2.6% 和 4.3%。没有发现系统性偏差。从模具校准得出的 NIR 值不太准确（4.6% 偏差和 6.9% 偏差）。使用初始静脉样本作为体内校准提高了模具校准的准确性，但没有改变工作台校准的性能。结论。在测试条件下，使用光具座校准的实验相位调制近红外光谱系统与颈静脉样本估计的毛细血管饱和度一致。需要进一步的工作来证明系统在其他条件下的有效性能。
Objective. This study was undertaken to compare the cerebral oxygenation measured by an experimental phase-modulated near-infrared (NIR) spectroscopy system with capillary saturation estimated from jugular venous oxygen saturation. Methods. Jugular venous catheters were placed in 30 patients undergoing carotid endarterectomy and 194 measurements of venous oxygen saturation were obtained intra operatively. Simultaneous measurement of optical path length at 754, 785, and 816 nm was performed using a phase-modulated near-infrared spectroscopy system. Optical calibration was performed using both an optical bench and a scattering mold. Hemoglobin saturation was calculated from NIR measurements using equations derived from diffusion theory. Capillary saturation was calculated from the arterial and venous saturations. Results. Jugular venous saturations ranged from 41 to 92%. When calibrated using the optical bench, the NIR estimates of hemoglobin saturation deviated from estimated capillary values by an average of 2.6% bias and 4.3% deviation. No systematic bias was noted. NIR values derived from mold calibration were less accurate and precise (4.6% bias and 6.9% deviation.) Use of the initial venous sample as an in vivocalibration improved the accuracy of the mold calibration but did not alter the performance of the bench calibration. Conclusions. Under the conditions tested, an experimental phase-modulated near-infrared spectroscopy system calibrated using an optical bench agreed with capillary saturation estimated from jugular venous samples. Further work is necessary to demonstrate valid performance of the system under other conditions.