Innate and acquired bacteriophage-mediated immunity.
Innate and acquired bacteriophage-mediated immunity.
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DOI：
10.4161/bact.25857
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发表时间：
2013-07-01
期刊：
影响因子：
--
通讯作者：
Rohwer F
中科院分区：
文献类型：
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作者：
Barr JJ;Youle M;Rohwer F
我们最近描述了一种新的，非宿主来源的，噬菌体介导的免疫活性在粘膜表面，病原体进入后生动物的主要网站。在这项工作中，我们发现噬菌体T4通过其衣壳上展示的免疫球蛋白样结构域粘附于粘液糖蛋白。这种粘附将噬菌体定位在粘液表面，在那里它们更有可能遇到并杀死细菌，从而使噬菌体及其后生动物宿主都受益。我们提出了这种噬菌体后生动物共生的基础上，一个专门裂解模型的噬菌体感染。在这里，我们扩展了我们的噬菌体粘附粘液（BAM）模型，考虑无疑更复杂的体内动力学。我们假设粘液粘附性细菌，无论是溶解性的还是温和的，可能会影响肠道微生物群，并保护后生动物上皮免受细菌入侵。我们认为BAM可能提供先天性和获得性抗微生物免疫。
We recently described a novel, non-host-derived, phage-mediated immunity active at mucosal surfaces, the main site of pathogen entry in metazoans. In that work, we showed that phage T4 adheres to mucus glycoproteins via immunoglobulin-like domains displayed on its capsid. This adherence positions the phage in mucus surfaces where they are more likely to encounter and kill bacteria, thereby benefiting both the phage and its metazoan host. We presented this phage-metazoan symbiosis based on an exclusively lytic model of phage infection. Here we extend our bacteriophage adherence to mucus (BAM) model to consider the undoubtedly more complex dynamics in vivo. We hypothesize how mucus-adherent phages, both lytic and temperate, might impact the commensal microbiota as well as protect the metazoan epithelium from bacterial invasion. We suggest that BAM may provide both an innate and an acquired antimicrobial immunity.