Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children
Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children
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DOI：
10.1093/ajcn/80.2.447
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发表时间：
2004-08-01
影响因子：
7.1
通讯作者：
Michaelsen, KF
中科院分区：
文献类型：
--
作者：
Hoppe, C;Udam, TR;Michaelsen, KF
背景资料：来自发展中国家的研究表明，动物蛋白，特别是牛奶的摄入量与儿童期线性生长速度的提高有关。在蛋白质摄入量高的工业化国家，是否存在同样的关联尚不清楚。目的：我们的目的是研究蛋白质摄入量，血清胰岛素样生长因子I（sIGF-I）浓度和健康儿童身高之间的关联。设计：我们分析了2.5岁儿童蛋白质摄入量，sIGF-I浓度和身高之间的关联。结果：90名儿童（男54名）的第10、50和90天蛋白质摄入量分别为2.4、2.9和4.0g（. kg（-1）（.）d（-1），动物蛋白占63%。在校正性别和体重的多元线性回归中，身高（cm）与动物蛋白（g/d）[0.10 +/- 0.038（B +/- SE）; P = 0.01]和牛奶（0.0047 +/- 0.002; P = 0.007）摄入量呈正相关，但与植物蛋白或肉类摄入量无关。sIGF-I浓度与动物蛋白（1.4 +/- 0.53; P = 0.01）和牛奶（0.049 +/- 0.024; P = 0.045）的摄入量显著相关，但与植物蛋白或肉类的摄入量无关。sIGF-I浓度与身高呈正相关（0.019 ± 0.008; P = 0.02）。结论：牛奶摄入量与sIGF-I浓度和身高呈正相关。牛奶摄入量从200 mL/d增加到600 mL/d对应于循环IGF-I增加30%。这表明牛奶化合物对sIGF-I浓度具有刺激作用，从而对生长具有刺激作用。
Background: Studies from developing countries indicate that intake of animal protein, especially of milk, is associated with greater velocity of linear growth in childhood. Whether the same association exists in industrialized countries, where protein intake is high, is not clear.Objective: Our objective was to examine associations between protein intake, serum insulin-like growth factor I (sIGF-I) concentrations, and height in healthy children.Design: We analyzed the associations between protein intake, sIGF-I concentrations, and height in 2.5-y-old children. Diet (7-d record) and sIGF-I (radioimmunoassay) data were available from 90 children (54 boys).Results: The 10th, 50th, and 90th percentiles of protein intake were 2.4,2.9, and 4.0 g (.) kg(-1) (.) d(-1), respectively; 63% was animal protein. In multiple linear regressions with adjustment for sex and weight, height (cm) was positively associated with intakes of animal protein (g/d) [0.10 +/- 0.038 (b +/- SE); P = 0.01] and milk (0.0047 +/- 0.002; P = 0.007), but not with those of vegetable protein or meat. The sIGF-I concentration was significantly associated with intakes of animal protein (1.4 +/- 0.53: P = 0.01) and milk (0.049 +/- 0.024; P = 0.045), but not with those of vegetable protein or meat. sIGF-I concentrations were positively associated with height (0.019 +/- 0.008; P = 0.02).Conclusion: Milk intake was positively associated with sIGF-I concentrations and height. An increase in milk intake from 200 to 600 mL/d corresponded to a 30% increase in circulating IGF-I. This suggests that milk compounds have a stimulating effect on sIGF-I concentrations and, thereby, on growth.