Retinoic acid induces alveolar regeneration in the adult mouse lung
Retinoic acid induces alveolar regeneration in the adult mouse lung
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DOI：
10.1183/09031936.03.00119103
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发表时间：
2004-01-01
影响因子：
24.3
通讯作者：
Maden, M
中科院分区：
文献类型：
--
作者：
Hind, M;Maden, M
最近的数据表明，外源性维甲酸(RA)可以在实验性肺气肿的小鼠和大鼠模型中诱导肺泡再生，并扰乱肺泡发育。这可能是因为RA在正常的肺泡发育过程中是必需的，而随后提供的RA会重新唤醒发育过程中使用的基因级联反应。在这里，通过证明双硫兰干扰了这一过程，提供了进一步的证据，证明在小鼠的肺泡形成过程中需要RA。然后描述了出生后使用地塞米松破坏肺泡发育的进一步模型，进一步表明给这些成年小鼠注射RA可以使肺结构恢复到正常。因此，用维甲酸再生肺泡可能是一种重要的新的治疗方法，其特征是以气体交换表面积减少为特征的呼吸系统疾病，如支气管肺发育不良和肺气肿。
Recent data suggests that exogenous retinoic acid (RA) can induce alveolar regeneration in a mouse and a rat model of experimental emphysema and disrupted alveolar development. This may be because RA is required during normal alveolar development and the subsequent provision of RA reawakens the gene cascades used during development.Here, additional evidence that RA is required during alveologenesis in the mouse is provided by showing that disulphiram disrupts this process. A further model of disrupted alveolar development using dexamethasone administered postnatally is then described, and it is further shown that RA administered to these adult mice restores the lung architecture to normal.Alveolar regeneration with retinoic acid may therefore be an important novel therapeutic approach to the treatment of respiratory diseases characterised by a reduced gas-exchanging surface area, such as bronchopulmonary dysplasia and emphysema.