Photoredox-Induced Intramolecular 1,5-H Transfer Reaction of Aryl Iodides for the Synthesis of Spirocyclic gamma-Lactams
Photoredox-Induced Intramolecular 1,5-H Transfer Reaction of Aryl Iodides for the Synthesis of Spirocyclic gamma-Lactams
复制标题
光氧化还原诱导的芳基碘化物分子内 1,5-H 转移反应用于合成螺环 γ-内酰胺
DOI：
10.1021/acs.orglett.8b00731
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Xu Peng Fei
中科院分区：
文献类型：
--
作者：
Chen Jian Qiang;Chang Rui;Lin Jun Bing;Luo Yong Chun;Xu Peng Fei
This work develops a photocatalysis method for the synthesis of γ-spirolactams through a tandem intramolecular 1,5-HAT reaction–cyclization process. A variety of novel γ-spirolactams are prepared in good to excellent yields with this method. This transformation features mild reaction conditions and exceptional functional group tolerance. Additionally, γ-terpinene is applied to this transformation as a hydrogen atom donor for the first time.
