Contributions of medial prefrontal cortex to decision making involving risk of punishment.
Contributions of medial prefrontal cortex to decision making involving risk of punishment.
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DOI：
10.1016/j.neuropharm.2018.07.018
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发表时间：
2018-09-01
影响因子：
4.7
通讯作者：
Setlow B
中科院分区：
文献类型：
--
作者：
Orsini CA;Heshmati SC;Garman TS;Wall SC;Bizon JL;Setlow B
前额叶皮层（PFC）在多种形式的成本-收益决策中起着重要作用。然而，它对面临明确惩罚风险的决策的贡献尚未得到很好的理解。大鼠模型用于研究内侧PFC （mPFC）及其单胺能神经在风险决策任务（RDT）中的作用，在RDT中，大鼠在小的，“安全”的食物奖励和大的，“风险”的食物奖励之间进行选择，并伴有不同概率的轻度足电击惩罚。当惩罚概率在整个过程中增加时（“上行RDT”），mPFC的失活增加了对高风险大奖励的选择，但当惩罚概率在整个过程中减少时（“下行RDT”），mPFC的失活减少了对高风险大奖励的选择。相比之下，通过mpfc内安非他明增强单胺的可用性，只在下降RDT中减少了对大的、有风险的奖励的选择。在上行和下行RDT中，系统给药安非他明减少了对高风险大奖励的选择；然而，这种减少并没有因为同时mPFC失活而减弱，这表明mPFC并不是安非他明对冒险行为影响的关键位点。这些发现表明，mPFC在适应选择行为以应对不断变化的风险偶然性方面起着重要作用，但不一定在冒险行为本身中起作用。
The prefrontal cortex (PFC) plays an important role in several forms of cost-benefit decision making. Its contributions to decision making under risk of explicit punishment, however, are not well understood. A rat model was used to investigate the role of the medial PFC (mPFC) and its monoaminergic innervation in a Risky Decision-making Task (RDT), in which rats chose between a small, “safe” food reward and a large, “risky” food reward accompanied by varying probabilities of mild footshock punishment. Inactivation of mPFC increased choice of the large, risky reward when the punishment probability increased across the session (“ascending RDT”), but decreased choice of the large, risky reward when the punishment probability decreased across the session (“descending RDT”). In contrast, enhancement of monoamine availability via intra-mPFC amphetamine reduced choice of the large, risky reward only in the descending RDT. Systemic administration of amphetamine reduced choice of the large, risky reward in both the ascending and descending RDT; however, this reduction was not attenuated by concurrent mPFC inactivation, indicating that mPFC is not a critical locus of amphetamine’s effects on risk taking. These findings suggest that mPFC plays an important role in adapting choice behavior in response to shifting risk contingencies, but not necessarily in risk-taking behavior per se.
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影响因子：
3.3
作者：
Deng, Jay V.;Orsini, Caitlin A.;Setlow, Barry
通讯作者：
Setlow, Barry
影响因子：
2.6
作者：
Clark, L;Manes, F;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
3.3
作者：
Beas BS;McQuail JA;Ban Uelos C;Setlow B;Bizon JL
通讯作者：
Bizon JL
DOI：
10.1177/0269881113482532
发表时间：
2013-06
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Heal DJ;Smith SL;Gosden J;Nutt DJ
通讯作者：
Nutt DJ
影响因子：
5.3
作者：
CILIAX, BJ;HEILMAN, C;LEVEY, AI
通讯作者：
LEVEY, AI