Therapeutic potential of snake venom in cancer therapy: current perspectives
Therapeutic potential of snake venom in cancer therapy: current perspectives
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DOI：
10.1016/s2221-1691(13)60042-8
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发表时间：
2013-02-01
影响因子：
1.7
通讯作者：
Parmar, Utsav
中科院分区：
文献类型：
--
作者：
Vyas, Vivek Kumar;Brahmbhatt, Keyur;Parmar, Utsav
动物产生的许多活性分泌物已被用于开发治疗高血压和癌症等疾病的新药。蛇毒毒素对许多医疗条件的治疗做出了重大贡献。有许多已发表的研究描述和阐明了蛇毒的抗癌潜力。癌症治疗是使用源自不同物种动物的蛋白质肽和酶的主要领域之一。这些蛋白质或肽和酶中的一些在分离和评估时可能特异性地结合癌细胞膜，影响这些细胞的迁移和增殖。在蛇毒中发现的一些物质作为抗肿瘤剂具有很大的潜力。本文综述了近年来蛇毒抗肿瘤活性成分的研究进展。
Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to the treatment of many medical conditions. There are many published studies describing and elucidating the anti cancer potential of snake venom. Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species. Some of these proteins or peptides and enzymes front snake venom when isolated and evaluated may bind specifically to cancer cell membranes, affecting the migration and proliferation of these cells. Some of substances found in the snake venom present a great potential as anti tumor agent. In this review, we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity.