The consequences of not having eosinophils.
The consequences of not having eosinophils.
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作者：
Gleich GJ;Klion AD;Lee JJ;Weller PF
几条证据表明，嗜酸性粒细胞缺乏与任何特征性异常无关。缺乏嗜酸性粒细胞的患者，在免疫缺陷的情况下或由于IgG介导的嗜酸性粒细胞前体破坏，不显示任何与嗜酸性粒细胞减少相关的明显异常。嗜酸性粒细胞缺陷小鼠没有表现出任何独特的综合征或健康状况的下降，这一观察结果证明，在普通实验室条件下，嗜酸性粒细胞在哺乳动物的健康中并不起关键作用。鉴于这些发现，观察到白细胞介素-5（IL-5）的单克隆抗体耐受性良好似乎并不令人惊讶。例如，患有嗜酸性粒细胞增多综合征的患者已经接受美泊利单抗（一种抗IL-5单克隆抗体）长达6年，并且没有发生任何特征性的不良事件。瑞利珠单抗（另一种抗IL-5单克隆抗体）和贝那利珠单抗（IL-5受体α链的单克隆抗体）的安全性数据相对有限，尤其是贝那利珠单抗，尽管这些抗体用于人体的报告表明其耐受性良好。因此，到目前为止的数据表明，嗜酸性粒细胞的减少似乎对正常健康没有特征性的不良影响，并且消耗嗜酸性粒细胞的单克隆抗体具有广泛用于治疗嗜酸性粒细胞相关疾病的潜力。
Several lines of evidence suggest that deficiency of eosinophils is not associated with any characteristic abnormality. Patients lacking eosinophils, in the setting of immunodeficiency or as a consequence of IgG-mediated eosinophil precursor destruction, do not display any distinguishing abnormalities related to eosinophil reduction. The observation that eosinophil-deficient mice do not display any distinctive syndrome or failure of their health is evidence that, under ordinary laboratory conditions, the eosinophil does not play a critical role in the well-being of mammals. Observations that monoclonal antibodies to interleukin-5 (IL-5) are well tolerated appear unsurprising in light of these findings. For example, patients with the hypereosinophilic syndrome have received mepolizumab, an anti-IL-5 monoclonal antibody, for as long as 6 years and have not developed any characteristic set of adverse events. Safety data for reslizumab, another anti-IL-5 monoclonal antibody, and benralizumab, a monoclonal antibody to the IL-5 receptor α-chain, are comparatively limited, especially for benralizumab, although reports of administration of these antibodies to humans suggest that they are well tolerated. Thus, data to the present suggest that reduction of eosinophils appears to have no characteristic ill effects on normal health, and monoclonal antibodies that deplete eosinophils have the potential to be widely employed in the treatment of eosinophil-associated diseases.
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影响因子：
15.3
作者：
Jacobsen, Elizabeth A.;Ochkur, Sergei I.;Pero, Ralph S.;Taranova, Anna G.;Protheroe, Cheryl A.;Colbert, Dana C.;Lee, Nancy A.;Lee, James J.
通讯作者：
Lee, James J.
影响因子：
4.6
作者：
Ghazi A;Trikha A;Calhoun WJ
通讯作者：
Calhoun WJ
影响因子：
4.4
作者：
Fabre, Valeria;Beiting, Daniel P.;Appleton, Judith A.
通讯作者：
Appleton, Judith A.
影响因子：
14.2
作者：
Hart, TK;Cook, RM;Herzyk, DJ
通讯作者：
Herzyk, DJ
DOI：
10.1164/rccm.201103-0396oc
发表时间：
2011-11-15
影响因子：
24.7
作者：
Castro, Mario;Mathur, Sameer;Nair, Parameswaran
通讯作者：
Nair, Parameswaran