Intact neural activity during a Go/No-go task is associated with high global functioning in schizophrenia
Intact neural activity during a Go/No-go task is associated with high global functioning in schizophrenia
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DOI：
10.1111/pcn.12389
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发表时间：
2016-07-01
影响因子：
11.9
通讯作者：
Kasai, Kiyoto
中科院分区：
文献类型：
--
作者：
Araki, Tsuyoshi;Kirihara, Kenji;Kasai, Kiyoto
AimGo/No-go事件相关电位（ERP）信号已被广泛用于精神分裂症的研究，以监测这种疾病的自我控制缺陷。然而，迄今为止还没有研究将Go/No-go相关的ERP与全球功能联系起来。方法参与者包括21名精神分裂症患者和22名健康对照。本研究采用视觉Go/No-go范式，通过64电极脑电记录帽测量与Go/No-go相关的N2/P3 ERP成分。结果精神分裂症患者N2波幅降低，但不受Go/No-go条件的影响。P3波幅受Go/No-go条件的影响，但在精神分裂症患者中并没有降低。全球功能与否去P3振幅，但不N2振幅，在patients with schizophrenia.ConclusionThese结果表明，全球功能与完整的神经活动，而不是受损的神经活动在去/否去反应抑制任务在精神分裂症患者。
AimGo/No-go derived event-related potential (ERP) signals have been widely used in schizophrenia research to monitor self-control deficits in this disorder. However, no study to date has associated Go/No-go-related ERP with global functioning.MethodsParticipants consisted of 21 patients with schizophrenia and 22 healthy controls. We used a visual Go/No-go paradigm to measure Go/No-go-related N2/P3 ERP components by means of a 64-electrode cap for electroencephalogram recording. We used the Global Assessment of Functioning to evaluate global functioning and analyzed the correlation between ERP indices and global functioning scores.ResultsN2 amplitudes were reduced in patients with schizophrenia, but not influenced by either of the Go/No-go conditions. P3 amplitudes were influenced by the Go/No-go conditions, but not reduced in patients with schizophrenia. Global functioning was correlated with the No-go P3 amplitudes, but not N2 amplitudes, in patients with schizophrenia.ConclusionThese results indicate that global functioning is associated with intact neural activity rather than impaired neural activity during Go/No-go response inhibition tasks in patients with schizophrenia.