Influence of Age on the Association Between Various Measures of Obesity and All-Cause Mortality
Influence of Age on the Association Between Various Measures of Obesity and All-Cause Mortality
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DOI：
10.1111/j.1532-5415.2009.02486.x
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发表时间：
2009-11-01
影响因子：
6.3
通讯作者：
Ardern, Chris I.
中科院分区：
文献类型：
--
作者：
Kuk, Jennifer L.;Ardern, Chris I.
目的确定各种简单的肥胖指标与全因死亡风险在年轻和老年男性和女性之间的相关性是否不同。设计前瞻性队列研究，对死亡关联进行8.7+/-0.2年的随访。收集1988年至1994年的第三次全国健康与营养检查调查。对1000名男性和5166名女性进行肥胖测量。测量肥胖的指标包括体重、腰围、腰臀比、臀围、皮褶总数和生物电阻抗。结果所有和腹型肥胖与年轻人的死亡风险更大(P<65)。总体而言，腹型肥胖的相关性比总体肥胖或脱脂体重的相关性更强。结论肥胖对死亡风险的不利影响只有在65岁以下的成年人中才明显。根据几种不同的衡量标准，肥胖通常与老年人更大的死亡风险无关。虽然减肥有益于降低任何年龄段肥胖成年人的发病率，但目前尚不清楚减肥是否对降低老年人的死亡风险同样有益。
OBJECTIVESTo determine whether the association between various simple measures of obesity and risk for all-cause mortality differs between younger and older men and women.DESIGNProspective cohort study with 8.7 +/- 0.2 years of follow-up for mortality linkage.SETTINGThird National Health and Nutrition Examination Survey, 1988 to 1994.PARTICIPANTSFour thousand, four hundred thirty-seven men and 5,166 women.MEASUREMENTSMeasures of obesity included body mass, waist circumference, waist-to-hip ratio, hip circumference, sum of skinfolds, and bioelectrical impedance.RESULTSOverall and abdominal obesity are associated with greater mortality risk in younger adults (< 65) (P 65). In general, the association was stronger with measures of abdominal obesity than with measures of overall obesity or fat-free mass.CONCLUSIONThe adverse effects of obesity on mortality risk are apparent only in adults younger than 65. Obesity as characterized using several different measures was not generally associated with greater mortality risk in older adults. Although weight loss is beneficial for reducing morbidity in obese adults of any age, it is unclear whether weight loss is equally beneficial for reducing mortality risk in older adults.