Common marmoset as a model primate for study of the motor control system
Common marmoset as a model primate for study of the motor control system
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DOI：
10.1016/j.conb.2020.02.013
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发表时间：
2020-10-01
影响因子：
5.7
通讯作者：
Ebina, Teppei
中科院分区：
文献类型：
--
作者：
Matsuzaki, Masanori;Ebina, Teppei
普通绒猴（Callithrix jacchus）是一种新大陆猴，正在成为生物医学和神经科学研究的一种有前途的动物模型。这个物种与人类和其他灵长类动物共享其基本的大脑结构，包括运动皮层区域的组织以及这些区域与其他区域之间的连接。它的小而无脑的大脑皮层适合于现代生物技术的应用。运动皮层的光遗传刺激诱导前肢运动，双光子钙成像允许检测多个运动皮层神经元中与前肢运动相关的活动。普通绒猴也有大量的前肢相关行为和声音交流。因此，普通绒猴是研究前肢自主运动、社会行为及其功能障碍的良好模型。
The common marmoset (Callithrix jacchus), a New World monkey, is emerging as a promising animal model for biomedical and neuroscience research. This species shares its basic brain architecture, including the organization of the motor cortical areas and the connections between these and other areas, with humans and other primates. Its small and lissencephalic cerebral cortex is suitable for the application of modern biological techniques. Optogenetic stimulation of the motor cortex induces forelimb movements, and two-photon calcium imaging allows detection of forelimb movement-related activity in multiple motor cortical neurons. The common marmoset also has a large repertoire of forelimb-related behaviors and vocal communications. Thus, the common marmoset is a good model for research into voluntary forelimb movements, social behaviors, and their dysfunctions.