HYPERINSULINEMIA IN PRE-WEANING DIABETES (DB) MICE
HYPERINSULINEMIA IN PRE-WEANING DIABETES (DB) MICE
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DOI：
10.1007/bf01221993
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发表时间：
1974-01-01
期刊：
影响因子：
8.2
通讯作者：
HUMMEL, KP
中科院分区：
文献类型：
--
作者：
COLEMAN, DL;HUMMEL, KP
以糖尿病（db）基因和紧密相连的misty (m)基因偶联在同一染色体上，培育了两株糖尿病小鼠（C57BL/ KsJ-m）新菌株C57BL/6J-m db。这使得糖尿病小鼠（m db/m db）可以在4天大的时候通过灰色毛色和白色脚来识别，远远早于肥胖或糖尿病迹象的出现。两种品系的糖尿病小鼠在10日龄时均出现明显的高胰岛素血症，且其严重程度随年龄的增长而逐渐增加。血浆胰岛素浓度升高与轻度低血糖有关。两株糖尿病小鼠的高胰岛素血症或低血糖程度无显著差异。在高胰岛素血症的糖尿病小鼠中观察到的轻度低血糖表明，胰岛素抵抗早在10天大时就发生了，并且本身可能是导致高胰岛素血症的一个因素。在糖尿病小鼠中发生的早期事件的顺序似乎是高胰岛素血症导致轻度低血糖，然后是代偿性贪食，进而导致胰岛素分泌增强和肥胖。
Two new strains of diabetes mice (C57BL/ KsJ-m dband C57BL/6J-m db) have been developed with diabetes (db) and the closely linked misty (m) gene coupled on the same chromosome. This permits identification of diabetes mice (m db/m db) by their gray coat color and white feet as early as age 4 days, well before obesity or signs of diabetes are visible. Hyperinsulinemia was evident in diabetes mice of both strains at 10 days of age and the severity increased progressively with age. These elevated concentrations of plasma insulin were associated with mild hypoglycemia. No significant differences were observed with respect to the degrees of hyperinsulinemia or hypoglycemia between diabetes mice of the two strains. The mild hypoglycemia observed in diabetes mice in the presence of a pronounced hyperinsulinemia suggests that insulin resistance occurs as early as age 10 days and may itself be a factor in causing hyperinsulinemia. The sequence of early events occurring in diabetes mice appears to be hyperinsulinemia leading to mild hypoglycemia, followed by compensatory hyperphagia which in turn results in enhanced insulin secretion and obesity.