Design of simulated moving bed processes under reduced purity requirements.
Design of simulated moving bed processes under reduced purity requirements.
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降低纯度要求下的模拟移动床工艺设计
DOI:
10.1016/j.chroma.2007.02.063
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发表时间:
2007
期刊:
影响因子:
--
通讯作者:
A. Kienle
中科院分区:
文献类型:
--
作者:
M. Kaspereit;A. Seidel-Morgenstern;A. Kienle
The design of simulated moving bed chromatography under reduced purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory.
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