Are Ulcerative and Nonulcerative Interstitial Cystitis/Painful Bladder Syndrome 2 Distinct Diseases? A Study of Coexisting Conditions
Are Ulcerative and Nonulcerative Interstitial Cystitis/Painful Bladder Syndrome 2 Distinct Diseases? A Study of Coexisting Conditions
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DOI：
10.1016/j.urology.2011.04.030
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发表时间：
2011-08-01
期刊：
影响因子：
2.1
通讯作者：
Boura, Judith A.
中科院分区：
文献类型：
--
作者：
Peters, Kenneth M.;Killinger, Kim A.;Boura, Judith A.
与间质性膀胱炎/膀胱疼痛综合征（IC/PBS）相关的共存疾病尚未通过IC/PBS亚型进行充分研究。我们比较了共病的诊断/症状的妇女溃疡性（ULC）和非溃疡性（N-ULC）IC/PBS和controls.METHODS成年妇女IC/PBS和对照组没有IC/PBS完成了邮寄调查评估21诊断。IC/PBS亚型通过水扩张报告确定。标准化问卷评估IC/PBS症状（间质性膀胱炎症状/问题指数[ICSI-PI]）和未诊断的纤维肌痛、肠易激综合征和抑郁（症状强度评分[SIS];罗马III肠功能问卷;流行病学研究中心抑郁量表[CES-D]）。数据分析采用皮尔逊卡方检验，Fisher精确，Wilcoxon秩检验，或斯皮尔曼秩相关系数。结果178 N-ULC IC/PBS患者，36 ULC IC/PBS患者，和425对照组，ULC IC/PBS受试者年龄较大（中位数63岁; P <0.01），就业较少（P <0.01），但其他人口统计学特征组相似。N-ULC报告的慢性诊断（平均3.5 +/- 2.3）比ULC（2.3 +/- 2.0）和对照组（1.2 +/- 1.5）（P <0.01）。当比较N-ULC和ULC IC/PBS患者时，更多的N-ULC IC/PBS患者患有纤维肌痛（P =.03）、偏头痛（P =.03）、颞下颌关节紊乱（P < .01），以及更高的CES-D（P = .02）和SIS评分（P < .01）。ULC IC/PBS组在白天（P = 0.03）和夜间（P <0.01）排尿更频繁，平均膀胱容量小于N-ULC（P <0.01）。在ICSI-PI和罗马III上，N-ULC和ULC IC/PBS患者之间没有显著差异。结论IC/PBS亚型和对照之间的共病诊断和症状数量存在显著差异。亚型应继续单独评估，以确定其他相似性和差异。泌尿学78：301-308，2011年。(C)2011 Elsevier Inc.
OBJECTIVES Coexisting conditions associated with interstitial cystitis/painful bladder syndrome (IC/PBS) have not been fully explored by IC/PBS subtypes. We compared comorbid diagnoses/symptoms in women with ulcerative (ULC) and nonulcerative (N-ULC) IC/PBS and controls.METHODS Adult women with IC/PBS and controls without IC/PBS completed a mailed survey assessing for 21 diagnoses. IC/PBS subtype was determined by hydrodistention reports. Standardized questionnaires assessed IC/PBS symptoms (Interstitial Cystitis Symptom/Problem Indexes [ICSI-PI]) and for undiagnosed fibromyalgia, irritable bowel syndrome, and depression (Symptom Intensity Score [SIS]; Rome III Functional Bowel Questionnaire; Center for Epidemiologic Studies Depression Scale [CES-D]). Data were analyzed using the Pearson chi-square, Fisher exact, Wilcoxon rank test, or Spearman rank correlation coefficient.RESULTS Of 178 N-ULC IC/PBS patients, 36 ULC IC/PBS patients, and 425 controls, ULC IC/PBS subjects were older (median 63 years; P < .01) and less employed (P < .01), but groups were similar on other demographic characteristics. N-ULC reported more chronic diagnoses (mean 3.5 +/- 2.3) than ULC (2.3 +/- 2.0) and controls (1.2 +/- 1.5) (P < .01). When N-ULC and ULC IC/PBS patients were compared, more N-ULC IC/PBS patients had fibromyalgia (P = .03), migraines (P = .03), temporomandibular joint disorder (P < .01), and higher CES-D (P = .02) and SIS scores (P < .01). The ULC IC/PBS group voided more frequently during the daytime (P = .03) and nighttime (P < .01) and had smaller mean bladder capacity than N-ULC (P < .01). No significant differences were seen between N-ULC and ULC IC/PBS patients on the ICSI-PI and Rome III.CONCLUSIONS Notable differences in the number of comorbid diagnoses and symptoms were seen between IC/PBS subtypes and controls. Subtypes should continue to be evaluated individually to ascertain other similarities and differences. UROLOGY 78: 301-308, 2011. (C) 2011 Elsevier Inc.